1253056-01-7 Usage
Description
(R/S)-3-hydroxy-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one is a complex organic compound characterized by its triazolopyrazine and trifluorophenyl moieties. It is a chiral molecule, existing in both R and S configurations, and serves as a crucial intermediate in the pharmaceutical industry due to its role in the synthesis of specific drug compounds.
Uses
Used in Pharmaceutical Industry:
(R/S)-3-hydroxy-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one is used as an intermediate in the synthesis of 3-Desamino-2,3-dehydro Sitagliptin (D281985), which is an impurity of Sitagliptin (S491000). Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor that has been approved for the therapy of type II diabetes. The compound plays a significant role in ensuring the purity and efficacy of Sitagliptin, contributing to the development and production of treatments for diabetes patients.
Check Digit Verification of cas no
The CAS Registry Mumber 1253056-01-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,3,0,5 and 6 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1253056-01:
(9*1)+(8*2)+(7*5)+(6*3)+(5*0)+(4*5)+(3*6)+(2*0)+(1*1)=117
117 % 10 = 7
So 1253056-01-7 is a valid CAS Registry Number.
1253056-01-7Relevant articles and documents
EXPEDIENT SYNTHESIS OF SITAGLIPTIN
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Paragraph 00371; 00372, (2015/09/23)
Novel intermediates are disclosed as intermediates for preparation of a Sitagliptin. A novel synthetic method to prepare Sitagliptin using the said intermediates is also disclosed.
PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND ITS INTERMEDIATES
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Page/Page column 52-53, (2010/11/05)
The present invention relates to novel and improved processes for the preparation of Sitagliptin compound of formula (1) and its intermediates.
Direct asymmetric reductive amination
Steinhuebel, Dietrich,Sun, Yongkui,Matsumura, Kazuhiko,Sayo, Noboru,Saito, Takao
supporting information; experimental part, p. 11316 - 11317 (2011/03/19)
(Chemical Equation Presented) Asymmetric reductive amination of β-keto amides catalyzed by the chiral catalyst Ru(OAc)2 ((R)-dm-segphos) produces unprotected β-amino amides with high yields and high enantioselectivities (94.7-99.5% ee). This "one-pot" methodology is general in substrate scope and has been successfully employed to produce sitagliptin with 99.5% ee and 91% assay yield. The excellent reaction efficiency is attributed to the remarkable tolerance to high concentrations of ammonium ion, the high chemoselectivity, and the high enantioselectivity (99.5% ee) of the Ru catalyst system.