125328-80-5

Basic information

• Product Name: N-(4-BROMO-3-CHLORO-2-METHYL-PHENYL) ACETAMIDE
• Synonyms: N-(4-Bromo-3-chloro-2-methylphenyl)acetamide;Acetamide, N-(4-bromo-3-chloro-2-methylphenyl)-
• CAS NO: 125328-80-5
• Molecular Formula: C₉H₉BrClNO
• Molecular Weight: 262.53
• Product Categories: Anilines, Amides & Amines;Bromine Compounds;Chlorine Compounds
• Mol File: 125328-80-5.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 368.5 °C at 760 mmHg
• Flash Point: 176.7 °C
• Appearance: /
• Density: 1.572g/cm³
• Vapor Pressure: 1.27E-05mmHg at 25°C
• Refractive Index: 1.61
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.58±0.70(Predicted)
• CAS DataBase Reference: N-(4-BROMO-3-CHLORO-2-METHYL-PHENYL) ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-BROMO-3-CHLORO-2-METHYL-PHENYL) ACETAMIDE(125328-80-5)
• EPA Substance Registry System: N-(4-BROMO-3-CHLORO-2-METHYL-PHENYL) ACETAMIDE(125328-80-5)

Safety Data

• Hazardous Substances Data: 125328-80-5(Hazardous Substances Data)

Usage

Description

N-(4-BROMO-3-CHLORO-2-METHYL-PHENYL) ACETAMIDE is an organic compound with the molecular formula C9H9BrClNO. It is characterized by its unique structure, which includes a bromo and chloro substituent on the phenyl ring, as well as a methyl group and an amide functional group. N-(4-BROMO-3-CHLORO-2-METHYL-PHENYL) ACETAMIDE is known for its potential applications in various chemical and pharmaceutical processes due to its versatile chemical properties.

Uses

Used in Chemical Synthesis:
N-(4-BROMO-3-CHLORO-2-METHYL-PHENYL) ACETAMIDE is used as a reagent for the synthesis of indoxyl-glycosides. These indoxyl-glycosides are essential in the monitoring of glycosidase activities, which are crucial enzymes involved in the metabolism of carbohydrates. The compound plays a vital role in the development of assays and diagnostic tools for studying the function and regulation of these enzymes.
Used in Pharmaceutical Research:
In the pharmaceutical industry, N-(4-BROMO-3-CHLORO-2-METHYL-PHENYL) ACETAMIDE may be utilized as a building block or intermediate in the development of new drugs. Its unique structure and functional groups can be exploited to create novel compounds with potential therapeutic applications. Researchers can use this compound to explore its interactions with various biological targets, such as proteins or enzymes, which could lead to the discovery of new drugs for treating various diseases.
Used in Material Science:
The compound's structural features and chemical properties may also make it a candidate for use in material science applications. It could potentially be incorporated into the development of new materials with specific properties, such as improved stability, reactivity, or selectivity in certain chemical processes. This could have implications for various industries, including electronics, coatings, and adhesives.

InChI:InChI=1/C9H9BrClNO/c1-5-8(12-6(2)13)4-3-7(10)9(5)11/h3-4H,1-2H3,(H,12,13)

Upstream product

• 7463-35-6 N-(3-chloro-2-methylphenyl)acetamide 
• 7726-95-6 bromine 
• 98-95-3 nitrobenzene 
• 87-60-5 3-chloro-2-methylbenzenamine 
• 627531-47-9 4-amino-2-chloro-3-methylbromobenzene 
• 108-24-7 acetic anhydride 

Downstream Products

• 1447125-25-8 C₁₅H₁₅BrClNO₄ 
• 125328-84-9 (5-Bromo-4-chloro-indol-3-yl)-β-L-fucopyranoside 
• 153248-52-3 5-bromo-4-chloro-indol-3-yl-(5-acetamido-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosylonic acid) 
• 125328-77-0 N-acetyl-5-bromo-6-chloroanthranilic acid 
• 3030-19-1 2-amino-5-bromo-6-chlorobenzoic acid 
• 97329-43-6 1-bromo-2-chloro-3-methyl-benzene 
• 1044256-89-4 1-bromo-3-(bromomethyl)-2-chlorobenzene 
• 7240-90-6 5-bromo-4-chloro-3-indolyl β-D-galactopyranoside 
• 1607828-63-6 (5-bromo-4-chloroindol-3-yl) (β-D-galactopyranosyl)-(1→4)-β-D-glucopyranoside 
• 6388-45-0 5-bromo-6-chloro-N-[(methoxycarbonyl)methyl]anthranilic acid methyl ester 
• 1421375-45-2 2-chloro-4-((3S,3aS,4S)-3,4-dimethoxy-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-3-methylbenzonitrile 
• 1421375-42-9 2-chloro-4-((3S,3aS,4S)-3-(cyclopropylmethoxy)-4-hydroxy-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-3-methylbenzonitrile 
• 1421376-02-4 4-((3S,3aR,4S)-4-((tert-butyldimethylsilyl)oxy)-3-(cyclopropylmethoxy)-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-2-chloro-3-methylbenzonitrile 
• 1421375-41-8 2-chloro-4-((3S,3aS,4S)-3-(2-fluoroethoxy)-4-hydroxy-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-2-chloro-3-methylbenzonitrile 

Relevant articles and documents

Synthetic method 5- of -4- (-1- I -3-)-(C)-(C)-ethyl-methyl-indol. (by machine translation)

To the method, the 3 - indole chromogenic 5 - substrate is obtained, by hydrolyzing the indole phenol with acetic. anhydride, under an acidic condition with acetic, anhydride to form an indole, chromogenic substrate by hydrolyzing the, indole phenol, with acetic anhydride under an acidic, condition with acetic anhydride under an acidic condition 5 - 5 . (by machine translation)

Indoxylic acid esters as convenient intermediates towards indoxyl glycosides

Indoxylic acid methyl and allyl esters with varied halide-substitution patterns were obtained in excellent yields using a scalable route. Phase-transfer glycosylation of these key intermediates was carried out with various glycosyl halides. Subsequent mild silver-mediated decarboxylation followed by Zemplen deacetylation led to indoxyl glycosides in good overall yields. Indoxyl glycosides are well-established and widely used tools for enzyme screening and enzyme-activity monitoring. In the past, their synthesis has been difficult, so this new approach has led to a variety of useful structures. Indoxyl glycosides with varied halide-substitution patterns were synthesized using indoxylic acid esters as key intermediates. Glycosylation under phase-transfer conditions, ester cleavage, and mild decarboxylation led to the indoxyl glycosides in good yields. This approach enables access to a number of different indoxyl compounds. Copyright

Novel efficient routes to indoxyl glycosides for monitoring glycosidase activities

A new efficient synthesis for broad access to indoxyl glycosides was developed. Indoxylic acid allyl ester linked to a sugar structure served as the key intermediate in this route. Selective ester cleavage and mild decarboxylation led to the corresponding indoxyl glycosides in good yields. This synthesis was applied for preparation of indoxyl glycosides of fucose, sialic acid, and 6′-sialyl lactose.