125353-44-8

Basic information

• Product Name: (S)-1,1,1-TRIFLUOROISOPROPYLAMINE HYDROCHLORIDE
• Synonyms: (S)-2-AMINO-1,1,1-TRIFLUOROPROPANE HYDROCHLORIDE;(S)-1,1,1-TRIFLUOROISOPROPYLAMINE HYDROCHLORIDE;S-TFIPMHCL;S-2,2,2-TRIFLUORO-1-(METHYL)ETHYLAMINE HYDROCHLORIDE;(2S)-1,1,1-trifluoropropan-2-aMine hydrochloride;(S)-1,1,1-TRIFLUOROISOPROPYLAMINE HYDROCHLORIDE, 1-trifluoropropane hydrochloride;(S)-1,1,1-Trifluoropropan-2-amine hydrochloride;(S)-2-Amino-1,1,1-trifluoropropane Hydrochloride,99%e.e.
• CAS NO: 125353-44-8
• Molecular Formula: C3H7ClF3N
• Molecular Weight: 149.54
• Mol File: 125353-44-8.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 116 °C at 760 mmHg
• Flash Point: 23.9 °C
• Appearance: off-white powder
• Vapor Pressure: 17.1mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: (S)-1,1,1-TRIFLUOROISOPROPYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1,1,1-TRIFLUOROISOPROPYLAMINE HYDROCHLORIDE(125353-44-8)
• EPA Substance Registry System: (S)-1,1,1-TRIFLUOROISOPROPYLAMINE HYDROCHLORIDE(125353-44-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 125353-44-8(Hazardous Substances Data)

Usage

General Description

(S)-1,1,1-Trifluoroisopropylamine hydrochloride is a chemical compound with the molecular formula CF3CH(CH3)NH2·HCl. It is a highly stable and reactive intermediate used in the synthesis of various pharmaceuticals and agrochemicals. (S)-1,1,1-TRIFLUOROISOPROPYLAMINE HYDROCHLORIDE is a colorless liquid with a strong ammonia-like odor. It is commonly used as a reagent in organic chemical reactions and as a building block in the synthesis of various organic compounds. Additionally, it is also employed in the production of pesticides and herbicides. This chemical has applications in the pharmaceutical, agrochemical, and fine chemical industries due to its unique properties and versatility in organic synthesis.

InChI:InChI=1/C3H6F3N.ClH/c1-2(7)3(4,5)6;/h2H,7H2,1H3;1H/t2-;/m0./s1

Upstream product

• 249648-15-5 C₃H₆F₃N*C₄H₆O₆ 
• 177268-09-6 (S)-2,2,2-Trifluoro-1-p-tolylsulfanylmethyl-ethylamine 
• 34226-10-3 1,1,1-trifluoropropanone oxime 
• 119561-24-9 N-benzylidene(1,1,1-trifluoroisopropyl)amine 
• 1998156-24-3 C₁₀H₁₀F₃NO 
• 811432-45-8 C₁₁H₁₄F₃N 

Relevant articles and documents

Cinchonium Betaines as Efficient Catalysts for Asymmetric Proton Transfer Catalysis: The Development of a Practical Enantioselective Isomerization of Trifluoromethyl Imines

We have developed a new class of cinchonium betaine catalysts bearing both a base moiety and an aromatic moiety as an N-substituent of the quinuclidine motif. These cinchonium betaines were found to promote proton transfer catalysis with 1000-5000 turnovers per 24 h, thereby enabling us to realize highly efficient enantioselective isomerization of trifluoromethyl imines to provide a practical access to optically active trifluoromethylated amines.

DEUTERATED ANALOGS OF AN ORGANIC COMPOUND

Provided are deuterated analogs of a compound and methods of using such deuterated analogs for treating a brain tumor in a patient in need thereof; the treatment comprising administering to the patient a deuterated compound described herein. The deuterated compound may be administered in combination with radiation therapy and/or an additional therapeutic agent.

Asymmetric synthesis of trifluoromethylated amines via catalytic enantioselective isomerization of imines

A new approach toward the asymmetric synthesis of optically active trifluoromethylated amines was enabled by an unprecedented, highly enantioselective catalytic isomerization of trifluoromethyl imines with a new chiral organic catalyst. Not only aryl but also alkyl trifluoromethylated amines could be obtained in high enantioselectivities.