125367-34-2

Basic information

• Product Name: BAPTA-tetramethyl Ester
• Synonyms: N,N'-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-(2-Methoxy-2-oxoethyl)glycine 1,1'-DiMethyl Ester;Glycine,N,N'-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-(2-Methoxy-2-oxoethyl)-,1,1'-diMethyl ester;Tetramethyl 2,2',2'',2'''-(((ethane-1,2-diylbis(oxy))-bis(2,1-phenylene))bis(azanetriyl))tetraace;bis(2,1-phenylene);bis(azanetriyl);Tetramethyl 2,2',2'',2'''-(((ethane-1,2-diylbis(oxy);Tetramethyl 2,2',2'',2'''-(((ethane-1,2-diylbis(oxy))-bis(2,1-phenylene))bis(azanetriyl))tetra;TetraMethyl 2,2',2'',2'''-(((ethane-1,2-diylbis(oxy))bis(2,1-phenylene))bis(azanetriyl))tetraacetate
• CAS NO: 125367-34-2
• Molecular Formula: C26H32N2O10
• Molecular Weight: 532.543
• Product Categories: Amines;Aromatics;Fluorescent Labels & Indicators;Chelating Agents & Ligands
• Mol File: 125367-34-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 93-95°C
• Boiling Point: 619.178 °C at 760 mmHg
• Flash Point: 328.267 °C
• Appearance: Off-white/Powder
• Density: 1.267
• Storage Temp.: -20°C Freezer
• PKA: 2.21±0.50(Predicted)
• CAS DataBase Reference: BAPTA-tetramethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: BAPTA-tetramethyl Ester(125367-34-2)
• EPA Substance Registry System: BAPTA-tetramethyl Ester(125367-34-2)

Safety Data

• Hazardous Substances Data: 125367-34-2(Hazardous Substances Data)

Usage

Description

BAPTA-tetramethyl Ester, a lipophilic diester derivative of BAPTA, is a white crystalline solid with unique chemical properties. It is specifically designed to inhibit the proteolytic activities of certain metalloproteinases, including calpain and TACE, making it a valuable compound in various applications.

Uses

Used in Pharmaceutical Industry:
BAPTA-tetramethyl Ester is used as an inhibitor for the proteolytic activities of metalloproteinases such as calpain and TACE. Its application in this industry is due to its ability to regulate the activity of these enzymes, which play crucial roles in various physiological and pathological processes.
Used in Research and Development:
In the field of research and development, BAPTA-tetramethyl Ester serves as a valuable tool for studying the functions and mechanisms of metalloproteinases. By inhibiting their activities, researchers can gain insights into the roles these enzymes play in cellular processes and disease progression.
Used in Drug Design and Development:
BAPTA-tetramethyl Ester is used as a lead compound in the design and development of new drugs targeting metalloproteinases. Its ability to inhibit the proteolytic activities of these enzymes makes it a promising starting point for the development of therapeutic agents for various diseases, including those involving abnormal metalloproteinase activity.
Used in Diagnostic Applications:
BAPTA-tetramethyl Ester can be employed in the development of diagnostic tools and assays to detect and measure the activity of metalloproteinases. By providing a means to inhibit these enzymes, it can help in the identification of potential biomarkers and the development of diagnostic tests for related diseases.

Upstream product

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Downstream Products

• 172646-18-3 5-amino 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetraacetoxymethyl ester 
• 172646-17-2 5-nitro 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetraacetoxymethyl ester 
• 1393818-11-5 C₅₇H₅₇Cl₂N₃O₂₁Si 
• 124251-83-8 5′-nitro-1,2-bis-(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid 
• 172646-43-4 5-nitro-BAPTA-tetramethyl ester 
• 172646-07-0 5-amino-1,2-bis(o-aminophenoxy)ethane-N,N,N’,N’-tetraacetic acid tetramethyl ester 

Relevant articles and documents

Real-Time Reaction Monitoring of an Organic Multistep Reaction by Electrospray Ionization-Ion Mobility Spectrometry

The capability of electrospray ionization (ESI)-ion mobility (IM) spectrometry for reaction monitoring is assessed both as a stand-alone real-time technique and in combination with HPLC. A three-step chemical reaction, consisting of a Williamson ether synthesis followed by a hydrogenation and an N-alkylation step, is chosen for demonstration. Intermediates and products are determined with a drift time to mass-per-charge correlation. Addition of an HPLC column to the setup increases the separation power and allows the determination of further species. Monitoring of the intensities of the various species over the reaction time allows the detection of the end of reaction, determination of the rate-limiting step, observation of the system response in discontinuous processes, and optimization of the mass ratios of the starting materials. However, charge competition in ESI influences the quantitative detection of substances in the reaction mixture. Therefore, two different methods are investigated, which allow the quantification and investigation of reaction kinetics. The first method is based on the pre-separation of the compounds on an HPLC column and their subsequent individual detection in the ESI-IM spectrometer. The second method involves an extended calibration procedure, which considers charge competition effects and facilitates nearly real-time quantification.