1253856-39-1

Basic information

• Product Name: 3-((S)-2-tert-butoxycarbonylamino-6-dimethylsulfoxonium-5-oxo-hexanoylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester
• Synonyms: 3-((S)-2-tert-butoxycarbonylamino-6-dimethylsulfoxonium-5-oxo-hexanoylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS NO: 1253856-39-1
• Molecular Weight: 377.502
• Mol File: 1253856-39-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-((S)-2-tert-butoxycarbonylamino-6-dimethylsulfoxonium-5-oxo-hexanoylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-((S)-2-tert-butoxycarbonylamino-6-dimethylsulfoxonium-5-oxo-hexanoylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester(1253856-39-1)
• EPA Substance Registry System: 3-((S)-2-tert-butoxycarbonylamino-6-dimethylsulfoxonium-5-oxo-hexanoylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester(1253856-39-1)

Safety Data

• Hazardous Substances Data: 1253856-39-1(Hazardous Substances Data)

Upstream product

• 91229-91-3 tert-butyl (S)-N-tert-butoxycarbonylpyroglutamate 
• 1774-47-6 trimethylsulfoxonium iodide 

Relevant articles and documents

Synthesis method of Avibactam intermediate

The invention discloses a synthesis method of an Avibactam intermediate, and belongs to the technical field of the medicine chemical synthesis. The synthesis method comprises the following steps: reacting pyroglutamate containing an amino protecting group with trimethylsulfoxonium iodide in a reaction solvent under the effect of the carbonate to obtain the Avibactam intermediate. The problems thata strong alkali process method in the prior art is large in potential safety hazard, relatively difficult in process control and high in impurity content are avoided, and the synthesis method disclosed by the invention is mild in reaction condition, simple in operation, high in process operability security, high in yield, high in product purity and suitable for the industrial production.