125425-47-0

Basic information

• Product Name: Cyclohexane, 2-fluoro-4-methyl-1-(1-methylethyl)-, (1S,2R,4R)- (9CI)
• Synonyms: Cyclohexane, 2-fluoro-4-methyl-1-(1-methylethyl)-, (1S,2R,4R)- (9CI)
• CAS NO: 125425-47-0
• Molecular Formula: C₁₀H₁₉F
• Molecular Weight: 158.2562632
• Product Categories: ISOPROPYL
• Mol File: 125425-47-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cyclohexane, 2-fluoro-4-methyl-1-(1-methylethyl)-, (1S,2R,4R)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexane, 2-fluoro-4-methyl-1-(1-methylethyl)-, (1S,2R,4R)- (9CI)(125425-47-0)
• EPA Substance Registry System: Cyclohexane, 2-fluoro-4-methyl-1-(1-methylethyl)-, (1S,2R,4R)- (9CI)(125425-47-0)

Safety Data

• Hazardous Substances Data: 125425-47-0(Hazardous Substances Data)

Upstream product

• 18419-38-0 (-)-menthol trimethylsilyl ether 
• 5564-44-3 O-(-)-menthyl S-methyl carbonodithioate 
• 2216-51-5 (-)-menthol 

Downstream Products

• 125425-50-5 (-)-menthylphosphonofluoridic acid 
• 125425-48-1 (-)-menthyltetrafluorophosphorane 

Relevant articles and documents

Observations on the Reaction of Xanthate Esters with 4-Methyl(difluoroiodo)benzene: a New Method for the Conversion of Alcohols to Alkyl Fluorides

Treatment of a range of S-methyldithiocarbonates (xanthates) with 4-methyl(difluoroiodo)benzene gives the corresponding alkyl fluorides.

A convenient synthesis of trifluoromethyl ethers by oxidative desulfurization-fluorination of dithiocarbonates

Trifluoromethyl ethers R-OCF3 are easily synthesized from the corresponding dithiocarbonates R-OCS2Me (R = aryl or primary alkyl) by a reagent system consisting of 70% HF/pyridine and an N-halo imide. When the reaction is applied to R-OCS2Me wherein R = secondary alkyl, tertiary alkyl, or benzylic group, fluorination leading to the corresponding alkyl fluorides R-F is achieved, whereas a combination of 50% HF/pyridine and N- bromosuccinimide affords the corresponding trifluoromethyl ethers R-OCF3 (R = secondary).

MENTHYL-SUBSTITUTED ORGANOPHOSPHORUS-COMPOUNDS. VII: FLUORINATED COMPOUNDS AND DERIVATIVES

The synthesis of a series of compounds, containing the (-)-menthyl group, bonded to tri-, tetra- and penta-coordinate phosphorus is described.Specifically, the formation of (-)-menthyltetrafluorophosphorane is described, based on the oxidative addition of (-)-menthyl fluoride to phosphorus trifluoride or by the oxidation-reduction reaction between (-)-menthyldichlorophosphine and arsenic trifluoride.The hydrolysis of (-)-menthyltetrafluorophosphorane was found to proceed stepwise, with formation of (-)-menthylphosphonofluoridic acid and, ultimately, (-)-menthylphosphonic acid. 1H-, 13C-, 19F- and 31P-NMR techniques were used to establish molecular structures of (-)-menthyl-substituted phosphorus compounds.Particular attention is drawn towards the chiral discrimination of geminal fluorine pairs in (-)-menthyl-P(X)F2 (X = :, O, S) compounds, giving rise to ABX spin systems in the 19F- and 31P-NMR spectra.Key words: Menthylphosphorus compounds; phosphorus-fluorine compounds; menthylphosphonic acid; chirality; NMR.