1254308-89-8

Basic information

• Product Name: C₃₀H₂₉N₇O₂
• CAS NO: 1254308-89-8
• Molecular Weight: 519.606
• Mol File: 1254308-89-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₀H₂₉N₇O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₀H₂₉N₇O₂(1254308-89-8)
• EPA Substance Registry System: C₃₀H₂₉N₇O₂(1254308-89-8)

Safety Data

• Hazardous Substances Data: 1254308-89-8(Hazardous Substances Data)

Upstream product

• 872171-59-0 3-(3-t-butyl-5-(3-(naphthalen-1-yl)ureido)-1H-pyrazol-1-yl)benzoic acid 
• 45588-79-2 1-(pyrimidin-4-yl)methanamine 

Relevant articles and documents

Biochemical and biophysical characterization of unique switch pocket inhibitors of p38α

Herein we describe the identification and characterization of a class of molecules that are believed to extend into a region of p38 known as the 'switch pocket'. Although these molecules lack a canonical hinge binding motif, they show Ki values as low as 100 nM against p38. We show that molecules that interact with this region of the protein demonstrate different binding kinetics than a canonical ATP mimetic, as well as a wide range of kinome profiles. Thus, the switch pocket presents new opportunities for kinome selectivity which could result in unique biochemical responses and offer new opportunities in the field of kinase drug discovery.