1254691-84-3Relevant articles and documents
Carboxyl radical-assisted 1,5-aryl migration through Smiles rearrangement
Hossian, Asik,Jana, Ranjan
supporting information, p. 9768 - 9779 (2016/10/31)
We report herein, a silver(i)-catalyzed Smiles rearrangement of 2-aryloxy- or 2-(arylthio)benzoic acids to provide aryl-2-hydroxybenzoate or aryl-2-mercaptobenzoate dimer, respectively, through 1,5-aryl migration from oxygen or sulfur to carboxylate oxygen. Mechanistically, the aryl ether moiety undergoes an intramolecular ipso attack by the carboxyl radical followed by a C-O or C-S bond cleavage. Aryl-2-mercaptobenzoates undergo oxidative dimerization through a thiol moiety in situ.
Design and synthesis of 2-phenoxynicotinic acid hydrazides as anti-inflammatory and analgesic agents
Moradi, Alireza,Navidpour, Latifeh,Amini, Mohsen,Sadeghian, Hamid,Shadnia, Hooman,Firouzi, Omidreza,Miri, Ramin,Ebrahimi, Seyed Esmaeil Sadat,Abdollahi, Mohammad,Zahmatkesh, Mona Haddad,Shafiee, Abbas
experimental part, p. 509 - 518 (2011/05/06)
A series of 2-phenoxynicotinic acid hydrazides were synthesized and evaluated for their analgesic and anti-inflammatory activities. Several compounds having an unsubstituted phenyl/4-pyridyl or C-4 methoxy substituent on the terminal phenyl ring showed moderate to high analgesic or antiinflammatory activity in comparison to mefenamic acid as the reference drug. The compounds with highest anti-inflammatory activity were subjected to in vitro COX-1/COX-2 inhibition assays and showed moderate to good COX-1 and weak COX-2 inhibition activities.