125473-34-9Relevant articles and documents
Diastereoselective synthesis of γ-hydroxy-β-amino alcohols and (2S,3S)-β-hydroxyleucine from chiral D-(N,N-dibenzylamino) serine (TBDMS) aldehyde
Laib,Chastanet,Zhu
, p. 1709 - 1713 (1998)
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A highly stereoselective synthesis of (2S,3S)-β-hydroxyleucine
Laib, Taoues,Chastanet, Jacqueline,Zhu, Jieping
, p. 1771 - 1772 (2007/10/03)
A highly diastereoselective nucleophilic addition of Grignard reagent to N,N-dibenzyl-O-TBS-serinal 3 was the key step in the present synthesis of (2S,3S)-β-hydroxyleucine 1.
A practical stereoselective synthesis of (2S, 3S)-3-hydroxyleucine
Williams, Lorenzo,Zhang, Zhongda,Ding, Xiaobin,Joullie, Madeleine M.
, p. 7031 - 7034 (2007/10/02)
A practical and convenient procedure is described for the preparation of gram quantities of (2S, 3S)-3-hydroxyleucine. The key step involves the triflate-mediated cyclization of spirooxazolidine 4 to the spirobicyclic compound 5, which is easily converted to the title compound in high yield.
