125494-59-9

Basic information

• Product Name: SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE
• Synonyms: 1-(4-Chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)cyclobutanemethanamine hydrochloride;[1-[1-(4-chlorophenyl)cyclobutyl]-3-methyl-butyl]-dimethyl-amine hydrate hydrochloride;1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethyl-butan-1-amine hydrate hydrochloride;1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine hydrate hydrochloride;1-(4-Chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)cyclobutanemethanamine hydrochloride monohydrate;Sibutramine Hydrochloride CIV (125 mg);)-SibutraMine-d6 HCl H2O;CyclobutaneMethanaMine,1-(4-chlorophenyl)-N,N-diMethyl-a-(2-Methylpropyl)-, hydrochloride, hydrate (1:1:1)
• CAS NO: 125494-59-9
• Molecular Formula: C17H29Cl2NO
• Molecular Weight: 334.32
• EINECS: 200-659-6
• Product Categories: CRESTOR;Anilines, Aromatic Amines and Nitro Compounds;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 125494-59-9.mol
• Article Data: 0

Chemical Properties

• Melting Point: 193-195.5°C
• Boiling Point: 342.6 °C at 760 mmHg
• Flash Point: 9℃
• Appearance: white/
• Density: 1.026 g/cm3
• Vapor Pressure: 7.45E-05mmHg at 25°C
• Storage Temp.: Room temp
• Solubility: DMSO: >30mg/mL
• CAS DataBase Reference: SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE(125494-59-9)
• EPA Substance Registry System: SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE(125494-59-9)

Safety Data

• Hazard Codes: Xi,T,F
• Statements: 36/37/38-39/23/24/25-23/24/25-11
• Safety Statements: 22-24/25-36-26-45-36/37-16-7
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 3
• Hazardous Substances Data: 125494-59-9(Hazardous Substances Data)

Usage

Description

SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE, also known as Meridia, is a pharmaceutical compound that acts as a serotonin and noradrenaline reuptake inhibitor (SNRI). It was introduced for the control of obesity, in conjunction with a reduced-calorie diet. Sibutramine can be prepared in four steps from 4-chlorobenzyl cyanide and is characterized by its white solid appearance.

Uses

1. Used in Pharmaceutical Industry:
SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE is used as an antiobesity agent for promoting weight loss. It works by decreasing calorie intake and increasing energy expenditure, creating a feeling of satiety and enhancing thermogenesis.
2. Used in Neurotransmitter Regulation:
SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE is used as a neurotransmitter reuptake inhibitor for modulating the levels of serotonin and noradrenaline in the brain, which contributes to its weight loss effects.
3. Used in Antihyperlipidemic Applications:
SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE is used as an antihyperlipidemic agent, potentially helping to manage and reduce high levels of lipids in the blood, which can be associated with obesity.
4. Used in Clinical Studies:
In clinical studies, Sibutramine has demonstrated meaningful weight loss sustained for up to 12 months in obese patients treated with 10 or 15 mg once-daily. Additionally, it has shown a lack of abuse potential, making it a safer option for weight management.
5. Used in Metabolite Research:
An appreciable part of Sibutramine's effect is due to its 2N-mono and didesmethyl metabolites, which are very potent monoamine reuptake inhibitors themselves, further contributing to its weight loss and neurotransmitter regulation properties.
Brand Names:
Meridia (Abbott)
Meridia, Reductil.

Originator

Knoll (Germany)

InChI:InChI=1/C17H26ClN.ClH.H2O/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14;;/h6-9,13,16H,5,10-12H2,1-4H3;1H;1H2