1254944-66-5 Usage
Description
SR8278 is a synthetic antagonist of the nuclear heme receptor REV-ERBα, which plays a crucial role in coordinating circadian rhythm and metabolic pathways in a heme-dependent manner. As an antagonist, SR8278 blocks the activation of REV-ERBα by the synthetic agonist GSK 4112, thereby modulating the expression of target genes involved in glucose production.
Uses
Used in Pharmaceutical Research:
SR8278 is used as a research tool for studying the role of REV-ERBα in various biological processes, particularly in the regulation of circadian rhythm and metabolism. Its ability to block the activation of REV-ERBα by GSK 4112 makes it a valuable compound for understanding the underlying mechanisms of these processes and their potential therapeutic applications.
Used in Metabolic Disorder Treatment:
SR8278 is used as a potential therapeutic agent for metabolic disorders, as it stimulates the expression of two REV-ERBα target genes, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, which are involved in the regulation of glucose production. This suggests that SR8278 may have potential applications in the treatment of conditions such as diabetes and other glucose metabolism-related disorders.
Used in Circadian Rhythm Regulation:
SR8278 is used as a compound to investigate the role of REV-ERBα in regulating circadian rhythm, as it has been shown to modulate the expression of target genes involved in this process. Understanding the role of REV-ERBα in circadian rhythm regulation may lead to the development of new treatments for sleep disorders and other conditions related to disrupted circadian rhythms.
Used in Pancreatic Alpha Cell Function Research:
SR8278 is used as a research tool to study the role of REV-ERBα in regulating glucagon secretion in pancreatic alpha cells. By working in conjunction with GSK 4112, SR8278 helps elucidate the mechanisms by which REV-ERBα influences glucagon secretion, which could have implications for the development of treatments for conditions such as hypoglycemia and other endocrine disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 1254944-66-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,4,9,4 and 4 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1254944-66:
(9*1)+(8*2)+(7*5)+(6*4)+(5*9)+(4*4)+(3*4)+(2*6)+(1*6)=175
175 % 10 = 5
So 1254944-66-5 is a valid CAS Registry Number.
1254944-66-5Relevant articles and documents
MODULATORS OF REV-ERB
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, (2015/07/16)
The subject matter herein concerns the identification and development of potent synthetic REV-ERB ligands, such as in vivo agonists and antagonists. These compounds allow for characterization of the effects of modulation of this receptor in vivo specifically on circadian behavior and metabolism, and have suitable characteristics for development of medicinal compounds useful for treatment of malconditions such as diabetes, obesity, atherosclerosis, dyslipidemia, a circadian rhythm disorder, coronary artery disease, bipolar disorder, depression, cancer, a sleep disorder, an anxiety disorder, an addiction disorder, a bone-related disorder such osteoporosis, a skeletal muscle disease, e.g., with compromised exercise capacity, or an autoimmune disorder such as psoriasis, multiple sclerosis, inflammatory bowel disease, and others.
