1255908-99-6

Basic information

• Product Name: (S)-1-nitro-5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-5H-thiophene[3,4-c]pyrrole-4,6-diketone
• Synonyms: (S)-1-nitro-5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-5H-thiophene[3,4-c]pyrrole-4,6-diketone
• CAS NO: 1255908-99-6
• Molecular Weight: 454.482
• Mol File: 1255908-99-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S)-1-nitro-5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-5H-thiophene[3,4-c]pyrrole-4,6-diketone(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-nitro-5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-5H-thiophene[3,4-c]pyrrole-4,6-diketone(1255908-99-6)
• EPA Substance Registry System: (S)-1-nitro-5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-5H-thiophene[3,4-c]pyrrole-4,6-diketone(1255908-99-6)

Safety Data

• Hazardous Substances Data: 1255908-99-6(Hazardous Substances Data)

Upstream product

• 4282-29-5 thiophene-3,4-dicarboxylic acid 
• 6007-85-8 1H,3H-thieno[3,4-c]furan-1,3-dione 
• 932032-15-0 2-nitrothiophene-3,4-dicarboxylic acid 
• 18853-32-2 3,4-dicyanothiophene 
• 1255909-27-3 (1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine N-acetyl-L-valine salt 
• 253168-94-4 2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine 
• 1255909-21-7 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)-N-(trimethylsilyl)ethylamine 
• 608141-42-0 (S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine 
• 932032-16-1 4-nitrothiophene[3,4-c]furan-1,3-diketone 

Downstream Products

• 1255909-03-5 (S)-N-(5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-4,6-dioxo-5,6-dihydro-4H-thiophene[3,4-c]pyrrole-1-yl)acetamide 
• 1255909-00-2 (S)-1-amino-5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-4H-thieno[3,4-c]pyrrole-4,6(5H)-dione 

Relevant articles and documents

CRYSTAL FORMS OF THIOPHENE DERIVATIVES

Disclosed is crystal form I of compound (S)—N-[5-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-4,6-dioxo-5,6-dihydro-4H-thieno[3,4-c]pyrrole-1-yl]acetamide.

BICYLIC COMPOUNDS AND METHODS OF USE

The present invention provides compounds that modulate protein function, specifically phosphodiesterase 4 (PDE4). The invention provides methods of treating, ameliorating, and/or preventing diseases, disorders, and conditions associated with PDE4. Compositions, including in combination with other inflammatory mediators, are also provided.