1256973-71-3Relevant articles and documents
N -(2-Pyridylmethyl)imines as azomethine precursors in catalytic asymmetric [3 + 2] cycloadditions
Padilla, Silvia,Tejero, Ruben,Adrio, Javier,Carretero, Juan C.
supporting information; experimental part, p. 5608 - 5611 (2011/03/20)
An efficient Cu(I)-catalyzed asymmetric [3 + 2] cycloaddition of N-(2-pyridylmethyl) imines has been developed. In the presence of a Cu(CH 3CN)4PF6/bisoxazoline catalyst system, high levels of enantioselectivity (up to 97% ee) and moderate to high exo selectivity were achieved with a wide variety of substituted dipolarophiles, including maleimides, fumarates, fumarodinitrile, enones, and nitroalkenes. The reaction with unsymmetrically substituted dipolarophiles is completely regioselective.