1257095-19-4Relevant articles and documents
Mechanism inspired development of rationally designed dihydrofolate reductase inhibitors as anticancer agents
Singh, Palwinder,Kaur, Matinder,Sachdeva, Shaveta
experimental part, p. 6381 - 6390 (2012/09/22)
On the basis of structural analysis of dihydrofolate reductase (DHFR) (cocrystallized separately with NADPH, dihydrofolate and NADPH, trimethoprim), compounds 2 and 3 were optimized for inhibition of DHFR. Appreciable tumor growth inhibitory activities of