1257220-36-2

Basic information

• Product Name: 4'-[3-(di-n-butylamino)propoxy]acetophenone
• Synonyms: 4'-[3-(di-n-butylamino)propoxy]acetophenone
• CAS NO: 1257220-36-2
• Molecular Weight: 305.461
• Mol File: 1257220-36-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4'-[3-(di-n-butylamino)propoxy]acetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-[3-(di-n-butylamino)propoxy]acetophenone(1257220-36-2)
• EPA Substance Registry System: 4'-[3-(di-n-butylamino)propoxy]acetophenone(1257220-36-2)

Safety Data

• Hazardous Substances Data: 1257220-36-2(Hazardous Substances Data)

Upstream product

• 115555-77-6 1-chloro-3-(di-n-butylamino)-propane hydrochloride 
• 36421-15-5 dibutyl-(3-chloro-propyl)-amine 
• 99-93-4 4-Hydroxyacetophenone 
• 91427-23-5 1-[4-(3-chloropropoxy)phenyl]ethanone 
• 111-92-2 dibutylamine 
• 2050-51-3 3-dibutylaminopropanol 
• 403-42-9 1-(4-fluorophenyl)ethanone 

Downstream Products

• 141626-36-0 dronedarone 
• 1333493-60-9 1-{4-[3-(di-n-butylamino)propoxy]phenyl}-1,3-heptanedione hydrochloride 
• 1333493-63-2 (2E,2'E)-3,3'-(1,4-butanediyldiimino)bis(1-{4-[3-(dibutylamino)propoxy]phenyl}-2-hepten-1-one) 
• 1333493-66-5 (2E)-1-{4-[3-(dibutylamino)propoxy]phenyl}-3-[(4-methoxyphenyl)amino]-2-hepten-1-one hydrochloride 
• 141645-23-0 (2-butyl-5-nitrobenzofuran-3-yl)(4-(3-(dibutylamino)propoxy)phenyl)methanone 
• 1356411-44-3 C₃₀H₄₃N₃O₅ 
• 141625-93-6 2-(n-butyl)-3-(4-{3-[di(n-butyl)amino]propoxy}benzoyl)-5-(methanesulfonamido)benzofuran hydrochloride 
• 1375149-24-8 C₃₁H₄₆N₂O₆S 
• 1375149-23-7 C₃₁H₄₆N₂O₆S 
• 1374967-92-6 (E/Z)-1-(4-(3-(dibutylamino)propoxy)phenyl)-3-(trimethylsilyloxy)hept-2-en-1-one 
• 1333493-68-7 1-{4-[3-(di-n-butylamino)propoxy]phenyl}-1,3-heptanedione 
• 1374967-93-7 (E)-1-(4-(3-(dibutylamino)propoxy)phenyl)-3-(dimethylamino)hept-2-en-1-one 

Relevant articles and documents

PROCESS FOR PREPARING BENZOFURAN DERIVATIVES SUBSTITUTED AT POSITION 5

The disclosure relates to a process for preparing benzofuran derivatives of general formula I: in which R, R1, and R2 are as defined in the disclosure; by coupling the hydroxylamine with a diketone of general formula III: in order to form an oxime that is then cyclized by heating in order to form the desired compound.

Process for the preparation of 3-aroyl-5-aminobenzofuran derivatives

The present invention relates to a process for the preparation of 3-aroyl-5-aminobenzofuran derivatives useful as antiarrhythmic drugs which avoids the use of nitro intermediates.

PROCESS FOR THE PRODUCTION OF BENZOFURANS

A process for the production of 2-alkyl-3-aroyl-5-nitrobenzofurans by acylation of 2-(2-hydroxy-5-nitrophenyl)-1-aryl-ethanones and subsequent treatment of the esters with combinations of bases and proton acids or Lewis acids. This process can be used for the production of Dronedarone. Furthermore, novel intermediates for the manufacture of Dronedarone are provided.