1257296-76-6 Usage
Chemical Compound
A compound formed by combining ketoprofen and glycerol.
Ketoprofen
A nonsteroidal anti-inflammatory drug (NSAID).
Glycerol
A simple polyol compound.
Improved Solubility
The ester form of ketoprofen allows for better solubility in comparison to its free acid form.
Enhanced Bioavailability
The ester form of ketoprofen improves its bioavailability, which can lead to better absorption and distribution within the body.
Pharmacological Properties
Retains the anti-inflammatory, analgesic, and antipyretic effects of ketoprofen.
Reduced Gastrointestinal Risks
Potentially reduces the risk of gastrointestinal irritation and ulceration associated with the free acid form of the drug.
Preclinical Studies
Has shown promise as a potential treatment for inflammatory conditions such as rheumatoid arthritis and osteoarthritis.
Unique Chemical Structure
The combination of ketoprofen and glycerol creates a unique chemical structure that contributes to its improved pharmaceutical characteristics.
Drug Development Potential
The improved properties of 1-O-ketoprofen glycerol ester make it a valuable candidate for further drug development and clinical investigation.
Check Digit Verification of cas no
The CAS Registry Mumber 1257296-76-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,7,2,9 and 6 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1257296-76:
(9*1)+(8*2)+(7*5)+(6*7)+(5*2)+(4*9)+(3*6)+(2*7)+(1*6)=186
186 % 10 = 6
So 1257296-76-6 is a valid CAS Registry Number.
1257296-76-6Relevant articles and documents
Biocatalytic synthesis and in vitro release of biodegradable linear polyesters with pendant ketoprofen
Wang, Hai-Yang,Zhang, Wei-Wei,Wang, Na,Li, Chao,Li, Kun,Yu, Xiao-Qi
, p. 3290 - 3293 (2010)
Enzyme-catalyzed polycondensation for the synthesis of polyester prodrugs of ketoprofen was reported. Lipase acrylic resin from Candida antarctica (CAL-B) was used to synthesize the linear polyesters with pendent ketoprofen groups based on ketoprofen glyc
