1257313-60-2Relevant articles and documents
Scaling out by microwave-assisted, continuous flow organic synthesis (MACOS): Multi-gram synthesis of bromo- and fluoro-benzofused Sultams Benzthiaoxazepine-1,1-dioxides
Ullah, Farman,Samarakoon, Thiwanka,Rolfe, Alan,Kurtz, Ryan D.,Hanson, Paul R.,Organ, Michael G.
scheme or table, p. 10959 - 10962 (2010/11/05)
(Figure Presented). Go with the flow! Using a combination of continuous-flow techniques and microwave irradiation, a 19-member collection of 5-10 gram quantities of benzthiaoxazepine-1,1-dioxides has been produced (see scheme). The elimination of intermediate- and largescale process optimization by invoking the concept of scale-out (rather than scale up) has significantly reduced the time necessary to prepare these compounds.