1257390-85-4

Basic information

• Product Name: methyl 3-(4-methylphenyl)indolizine-1-carboxylate
• Synonyms: methyl 3-(4-methylphenyl)indolizine-1-carboxylate
• CAS NO: 1257390-85-4
• Molecular Weight: 265.312
• Mol File: 1257390-85-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: methyl 3-(4-methylphenyl)indolizine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(4-methylphenyl)indolizine-1-carboxylate(1257390-85-4)
• EPA Substance Registry System: methyl 3-(4-methylphenyl)indolizine-1-carboxylate(1257390-85-4)

Safety Data

• Hazardous Substances Data: 1257390-85-4(Hazardous Substances Data)

Upstream product

• 110-86-1 pyridine 
• 100719-33-3 methyl 2-carbomethoxy-4-nitro-3-(4-methyl-phenyl)-butyrate 
• 17972-06-4 N-(4-methylbenzylidene)ethan-1-amine 
• 922-67-8 propynoic acid methyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 316375-85-6 methyl indolizine-1-carboxylate 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 1658-42-0 methyl 2-pyridylacetate 
• 766-97-2 4-n-methylphenylacetylene 
• 106-43-4 para-chlorotoluene 
• 5720-05-8 4-methylphenylboronic acid 

Relevant articles and documents

Silver-mediated synthesis of indolizines via oxidative C-H functionalization and 5-endo-dig cyclization

An efficient strategy for the synthesis of indolizines from readily available starting materials via oxidative C-H functionalization and 5-endo-dig cyclization in one step has been demonstrated. This protocol represents wide substrate scope, high function

Desulfitative palladium-catalyzed direct C-3 arylation of indolizines with arylsulfonyl chlorides

An efficient Pd-catalyzed desulfitative approach to C-3 arylation of indolizine derivatives has been developed, and the protocol uses readily available arylsulfonyl chlorides as the arylation reagent under nitrogen. This transformation was performed in a mixed solvent of 1-methyl-2-pyrrolidone and dimethoxyethane using simple triphenylphosphine as a ligand, which provides a new method for the C-3 arylation of indolizines. An efficient Pd-catalyzed desulfitative approach to C-3 arylation of indolizine derivatives has been developed, the protocol using readily available arylsulfonyl chlorides as the arylation reagent under nitrogen. This transformation proceeds in a mixed solvent of NMP and DME using simple triphenylphosphine a ligand, and provides a new method for the C-3 arylation of indolizines.

Iodine-promoted synthesis of 3-arylindolizine-1-carboxylates from 2-(2-nitro-1-arylethyl)malonates and pyridine

An efficient and straightforward one-pot synthetic protocol has been developed for the synthesis of 3-arylindolizine- 1-carboxylates via 1,3-dipolar annulation of 2-(2-nitro-1-arylethyl)malonates with pyridine and subsequent aromatisation in the presence of molecular iodine. The structure of methyl 3-(4-methoxyphenyl)indolizine-1-carboxylate (2a) and methyl 3-iodo-2-(4- nitrophenyl)indolizine-1-carboxylate (2f) was further confirmed by X-ray single crystal analysis. Website