1257529-92-2

Basic information

• Product Name: 2(3H)-Furanone, 5-[(1S,3S)-1-azido-3-[hydroxyl[4-Methoxy-3-(3-Methoxypropoxy)phenyl]Methyl]-4-Methylpentyl]dihydro-3-(1-Methylethyl)-, (3S,5S)-
• Synonyms: 2(3H)-Furanone, 5-[(1S,3S)-1-azido-3-[hydroxyl[4-Methoxy-3-(3-Methoxypropoxy)phenyl]Methyl]-4-Methylpentyl]dihydro-3-(1-Methylethyl)-, (3S,5S)-;5-[(1S,3S)-1-azido-3-[hydroxyl[4-Methoxy-3-(3-Methoxypropoxy)phenyl]Methyl]-4-Methylpentyl]dihydro-3-(1-Methylethyl)-, (3S,5S)-2(3H)-furanone
• CAS NO: 1257529-92-2
• Molecular Formula: C₂₅H₃₉N₃O₆
• Molecular Weight: 477.59366
• Mol File: 1257529-92-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2(3H)-Furanone, 5-[(1S,3S)-1-azido-3-[hydroxyl[4-Methoxy-3-(3-Methoxypropoxy)phenyl]Methyl]-4-Methylpentyl]dihydro-3-(1-Methylethyl)-, (3S,5S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Furanone, 5-[(1S,3S)-1-azido-3-[hydroxyl[4-Methoxy-3-(3-Methoxypropoxy)phenyl]Methyl]-4-Methylpentyl]dihydro-3-(1-Methylethyl)-, (3S,5S)-(1257529-92-2)
• EPA Substance Registry System: 2(3H)-Furanone, 5-[(1S,3S)-1-azido-3-[hydroxyl[4-Methoxy-3-(3-Methoxypropoxy)phenyl]Methyl]-4-Methylpentyl]dihydro-3-(1-Methylethyl)-, (3S,5S)-(1257529-92-2)

Safety Data

• Hazardous Substances Data: 1257529-92-2(Hazardous Substances Data)

Usage

General Description

"2(3H)-Furanone, 5-[(1S,3S)-1-azido-3-[hydroxyl[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-4-methylpentyl]dihydro-3-(1-methylethyl)-, (3S,5S)-" is a complex chemical compound that contains a furanone ring and several functional groups, including azide, hydroxyl, methoxy, and methyl. The molecule has a chiral center and is specifically classified as (3S,5S)- stereoisomer. It is composed of a mixture of carbon, hydrogen, oxygen, and nitrogen atoms arranged in a specific three-dimensional configuration. The compound's structure and properties may make it suitable for various potential applications in the fields of chemistry, pharmaceuticals, and materials science.

Upstream product

• 173154-01-3 (S)-3-((2S,4S)-4-azido-2-isopropyl-4-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)butanoyl)-4-benzyloxazolidin-2-one 
• 173154-03-5 (3S,5S)-5-[(1S,3S)-1-azido-3-(hydroxymethyl)-4-methylpentyl]-3-isopropyldihydrofuran-2(3H)-one 
• 173153-98-5 (2S,2'S,2S,4S)-2-[2-azido-2'-(4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-ethyl]-3-methylbutyric acid 
• 173154-02-4 (2S,4S)-4-azido-2-isopropyl-4-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]butanal 
• 1219468-81-1 4-iodo-1-methoxy-2-(3-methoxypropoxy)benzene 
• 173336-76-0 4-bromo-1-methoxy-2-(3-methoxypropoxy)benzene 

Downstream Products

• 1315181-73-7 (2S,4S)-4-azido-2-isopropyl-4-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-1-(4-methoxy-3-(3-methoxypropoxy)phenyl)butyl isobutyrate 
• 173334-57-1 (2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide 
• 1364791-11-6 aliskiren isobutyric acid salt 
• 1364791-13-8 (2S,4S,5S,7S)-4-amino-7-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-5-hydroxy-2-isopropyl-1-(4-methoxy-3-(3-methoxypropoxy)phenyl)-8-methylnonyl isobutyrate 
• 1364791-17-2 (2S,4S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-4-((2S,4S)-4-isopropyl-5-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidin-2-yl)butanamide 
• 1315181-75-9 (2S,4S,5S,7S)-7-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-4-azido-5-hydroxy-2-isopropyl-1-(4-methoxy-3-(3-methoxypropoxy)-phenyl)-8-methylnonyl isobutyrate 
• 1431951-65-3 C₃₂H₄₅NO₆ 
• 173338-07-3 tert-butyl (3S,5S,6S,8S)-8-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-ylcarbamate 
• 866030-35-5 tert-butyl {(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl}carbamate 
• 900811-48-5 3(S)-isopropyl-5(S)-{1(S)-amino-3(S)-isopropyl-4-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-butyl}-tetrahydrofuran-2-one 
• 1431951-69-7 C₃₂H₄₅NO₅ 
• 1431951-67-5 C₃₂H₄₅NO₇ 

Relevant articles and documents

A new synthetic route towards aliskiren intermediates

The synthesis of aliskiren intermediates was accomplished by attaching the 3,4-dialkoxyphenyl unit to precursor C-8 lactone-carboxylic acid derivatives using organometallic reagents. Totally different reactivities of the lactone-carboxylic acid chloride substrate towards organomagnesium and organoboron reagents were observed.

ALISKIREN INTERMEDIATES AND A PROCESS FOR ANALYZING THE PURITY OF ALISKIREN

The present invention provides aliskiren intermediates and impurities, and processes for preparation thereof. The present invention also provides processes for preparing aliskiren using these intermediates and impurities. These impurities can also be used as reference markers or reference standards in the determination of the purity of aliskiren or intermediates of aliskiren.