1257842-84-4

Basic information

• Product Name: 2-chloro-5-[[(5-(p-fluorophenyl)-1,3,4-oxadiazol-2-yl)thio]methyl]pyridine
• CAS NO: 1257842-84-4
• Molecular Weight: 321.762
• Mol File: 1257842-84-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-chloro-5-[[(5-(p-fluorophenyl)-1,3,4-oxadiazol-2-yl)thio]methyl]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-[[(5-(p-fluorophenyl)-1,3,4-oxadiazol-2-yl)thio]methyl]pyridine(1257842-84-4)
• EPA Substance Registry System: 2-chloro-5-[[(5-(p-fluorophenyl)-1,3,4-oxadiazol-2-yl)thio]methyl]pyridine(1257842-84-4)

Safety Data

• Hazardous Substances Data: 1257842-84-4(Hazardous Substances Data)

Upstream product

• 70258-18-3 2-chloro-5-(chloromethyl)pyridine 
• 41421-13-0 2-mercapto-5-(4-fluorophenyl)-1,3,4-oxadiazole 

Relevant articles and documents

Synthesis, biological evaluation, and molecular docking studies of 2-chloropyridine derivatives possessing 1,3,4-oxadiazole moiety as potential antitumor agents

A series of new 2-chloropyridine derivatives possessing 1,3,4-oxadiazole moiety were synthesized. Antiproliferative assay results indicated that compounds 6o and 6u exhibited the most potent activity against gastric cancer cell SGC-7901, which was more potent than the positive control. Especially, compound 6o exhibited significant telomerase inhibitory activity (IC 50 = 2.3 ± 0.07 μM), which was comparable to the positive control ethidium bromide. Docking simulation was performed to position compound 6o into the active site of telomerase (3DU6) to determine the probable binding model.