125789-07-3Relevant articles and documents
Novel non-peptide fibrinogen receptor antagonists. 1. Synthesis and glycoprotein IIb-IIIa antagonistic activities of 1,3,4-trisubstituted 2- oxopiperazine derivatives incorporating side-chain functions of the RGDF peptide
Sugihara, Hirosada,Fukushi, Hideto,Miyawaki, Toshio,Imai, Yumi,Terashita, Zen-Ichi,Kawamura, Masaki,Fujisawa, Yukio,Kita, Shunbun
, p. 489 - 502 (2007/10/03)
Based on the lead tetrapeptide RGDF, two possible non-peptide glycoprotein (GP) IIb-IIIa antagonists possessing an (S)-2-oxopiperazine-3- acetic acid moiety as a scaffold incorporating the indispensable Asp fragment were prepared, and (S)-4-[[trans-[4-(gu