1257984-85-2

Basic information

• Product Name: (S )-(+)-tert-butyl 2-(4-methoxybenzyl)pyrrolidine-1-carboxylate
• Synonyms: (S )-(+)-tert-butyl 2-(4-methoxybenzyl)pyrrolidine-1-carboxylate
• CAS NO: 1257984-85-2
• Molecular Weight: 291.39
• Mol File: 1257984-85-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (S )-(+)-tert-butyl 2-(4-methoxybenzyl)pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (S )-(+)-tert-butyl 2-(4-methoxybenzyl)pyrrolidine-1-carboxylate(1257984-85-2)
• EPA Substance Registry System: (S )-(+)-tert-butyl 2-(4-methoxybenzyl)pyrrolidine-1-carboxylate(1257984-85-2)

Safety Data

• Hazardous Substances Data: 1257984-85-2(Hazardous Substances Data)

Upstream product

• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 
• 696-62-8 para-iodoanisole 
• 338945-22-5 (S)-2-iodomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 202925-92-6 N-Pent-4-enylcarbamic acid tert-butyl ester 

Relevant articles and documents

Concise synthesis and applications of enantiopure spirobiphenoxasilin-diol and its related chiral ligands

The development of chiral architectures for chiral ligand and catalyst discovery is essential for asymmetric catalysis. Herein, we report the concise synthesis of a Si-centered spirocyclic skeleton, spirobiphenoxasilin-diol (SPOSiOL), and its derived chiral ligands. Using the chemical resolution method, the optical SPOSiOL could be obtained in high yield on a gram scale. Preliminary studies indicated that this ligand scaffold has great potential in transition metal-catalyzed asymmetric reactions. This finding further highlights that the Si-centered spirocyclic scaffolds are of great value in asymmetric catalysis. This journal is

DECARBOXYLATIVE CROSS-COUPLING AND APPLICATIONS THEREOF

Methods described herein enable the production of numerous molecular species through decarboxylative cross-coupling via use of photoredox and transition metal catalysts. For example, methods described herein enable the production of numerous molecular species through decarboxylative cross-coupling via use of photoredox and transition metal catalysts. A method described herein, in some embodiments, comprises providing a reaction mixture including a photoredox catalyst, a transition metal catalyst, a coupling partner and a substrate having a carboxyl group. The reaction mixture is irradiated with a radiation source resulting in cross-coupling of the substrate and coupling partner via a mechanism including decarboxylation, wherein the coupling partner is selected from the group consisting of a substituted aromatic compound and a substituted aliphatic compound.

Asymmetric palladium-catalyzed carboamination reactions for the synthesis of enantiomerically enriched 2-(Arylmethyl)- and 2-(Alkenylmethyl)pyrrolidines

The enantioselective synthesis of 2-(arylmethyl)- and 2-(alkenylmethyl) pyrrolidine derivatives via Pd-catalyzed alkene carboamination reactions is described. These transformations generate enantiomerically enriched products with up to 94% ee from readily