1258410-98-8Relevant articles and documents
Design, synthesis, and evaluation of resveratrol derivatives as Ass1-42 aggregation inhibitors, antioxidants, and neuroprotective agents
Lu, Chuanjun,Guo, Yueyan,Li, Jianheng,Yao, Meicun,Liao, Qiongfeng,Xie, Zhiyong,Li, Xingshu
supporting information, p. 7683 - 7687 (2013/02/21)
A series of novel resveratrol derivatives were designed, synthesised and evaluated as potential therapeutic agents for the treatment of Alzheimer's disease. Among these compounds, compound 7l, (E)-5-(4-(isopropylamino)styryl) benzene-1,3-diol, exhibited potent ss-amyloid aggregation inhibition activity, which was confirmed by a ThT fluorescence assay (71.65% at 20 μM) and transmission electron microscopy (TEM). Compound 7l also exhibited good antioxidant activity (4.12 Trolox equivalents in an oxygen radical absorbance capacity assay and a 37% reduction in reactive oxygen species in cells at 10 μM). The cytotoxicity analysis of compounds 7f, 7i, 7j and 7l indicated that these compounds have lower toxicities than resveratrol at 60 μM.
Synthesis of stilbene and distyrylbenzene derivatives through rhodium-catalyzed ortho -olefination and decarboxylation of benzoic acids
Mochida, Satoshi,Hirano, Koji,Satoh, Tetsuya,Miura, Masahiro
, p. 5776 - 5779 (2011/03/18)
Ortho-substituted benzoic acids efficiently undergo precisely ordered ortho-olefination/decarboxylation upon treatment with styrenes in the presence of a rhodium catalyst and silver salt oxidant to afford the corresponding meta-substituted stilbene deriva
