1258548-56-9Relevant articles and documents
Chiral primary amine thiourea promoted highly enantioselective Michael reactions of isobutylaldehyde with maleimides
Bai, Jian-Fei,Peng, Lin,Wang, Liang-Liang,Wang, Li-Xin,Xu, Xiao-Ying
, p. 8928 - 8932 (2010)
Chiral primary amine thiourea catalysts were first successfully applied to promote Michael addition of isobutyraldehyde to maleimides. A variety of N-aryl and N-aliphatic maleimides provided Michael adducts in excellent yields (up to 98%) and enantioselectivities (up to 99% ee) with 5 mol % catalyst.