125874-72-8Relevant articles and documents
Quinoid glycosides from Forsythia suspensa
Li, Chang,Dai, Yi,Zhang, Shu-Xiang,Duan, Ying-Hui,Liu, Ming-Li,Chen, Liu-Yuan,Yao, Xin-Sheng
, p. 105 - 113 (2014)
Phytochemical investigation on Forsythia suspensa (Thunb.) Vahl afforded 10 compounds, including quinoid glycosides, lignan glycosides, phenylethanoid glycoside and allylbenzene glycoside together with 13 known ones. Their structures were established based on extensive spectroscopic data analyses, including IR, UV, HRESIMS, 1D NMR and 2D NMR. Absolute configurations were determined by ECD calculation method and chemical degradation. In addition, all compounds were evaluated for their antiviral activity against influenza A (H1N1) virus and several were further evaluated against respiratory syncytial virus (RSV) in vitro. Among them, two previously known compounds showed significant activities against RSV with EC50 values of 3.43 and 6.72 μM.
Kinetic resolution of a dihydrobenzofuran-type neolignan by lipase-catalysed acetylation
Van Dyck, Stefaan M.O.,Lemiere, Guy L.F.,Jonckers, Tim H.M.,Dommisse, Roger,Pieters, Luc,Buss, Volker
, p. 785 - 789 (2001)
The kinetic resolution of 3,5′-dimethoxy-4′,7-epoxy-8,3′-neolignane-4,9,9′- triol 1 by lipase-catalysed acetylation in an organic solvent was investigated. Ten different lipases were screened for enantioselectivity in the reaction. The enantiomeric excess (e.e.) of the products was strongly dependent on the type of lipase used. After optimisation of the reaction conditions for Candida cylindracea lipase, the e.e. and yield of the reaction was improved greatly and, in some cases, the enantiomerically pure starting material 1 could be isolated, albeit in a low yield, with the acetylation affording predominantly (2R,3S)-1 and the (2S,3R)-esters.
Towards the specification of consecutive steps in macromolecular lignin assembly
Nose,Bernards,Furlan,Zajicek,Eberhardt,Lewis
, p. 71 - 79 (1995)
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Sesquineolignan and neolignan enantiomers from Triadica sebifera
Liu, Jin-Long,Wang, Su-Juan,Yu, Min,Zhang, Gui-Jie,Zhang, Yong-Li
, (2020/08/06)
Two pairs of new sesquineolignan enantiomers (1a/1b and 1c/1d), two pair of new 4′,7-epoxy-8,3′-neolignan enantiomers (2a/2b and 3a/3b), and a pair of new 3′,7-epoxy-8,4′-oxyneolignan enantiomers (4a/4b), along with two pairs of known 4′,7-epoxy-8,3′-neol
Neolignan Constituents with Potential Beneficial Effects in Prevention of Type 2 Diabetes from Viburnum fordiae Hance Fruits
Zhao, Chunchao,Chen, Jia,Shao, Jianhua,Shen, Jie,Li, Kehuan,Gu, Wenyan,Li, Sihui,Fan, Judi
, p. 10421 - 10430 (2018/10/15)
Nine new neolignan glycosides (1-9), viburfordosides A-I, two new neolignans, fordianes A and B (10, 11), and seven known analogues (12-18) have been isolated and identified from the fruits of Viburnum fordiae Hance. The structures and absolute configurations of undescribed neolignan constituents were identified by chemical methods and spectroscopic analyses. The α-glucosidase inhibitory, ABTS?+ and DPPH? scavenging, and anti-inflammatory activities of these secondary metabolites were evaluated. Some of them exhibited significant potency in inhibiting α-glucosidase and scavenging free radicals. Among the 14 metabolites that were found to have the capacity to inhibit NO production in LPS-stimulated RAW264.7 macrophage cells, compounds 2, 4, 6, 10, 11, 14, 17, and 18 were potent with IC50 values of 10.88-41.10 μM. These results support that V. fordiae fruits possessing the neolignan compounds may serve as both a functional food and a medicinal resource to prevent and treat type 2 diabetes (T2D).
