125903-81-3

Basic information

• Product Name: 3-(DIFLUOROMETHOXY)BENZYL ALCOHOL
• Synonyms: 3-(DIFLUOROMETHOXY)BENZYL ALCOHOL;RARECHEM AL BD 0447;alpha,alpha-Difluoro-3-(hydroxymethyl)anisole, [3-(Difluoromethoxy)phenyl]methanol;(3-(Difluoromethoxy)phenyl)methanol
• CAS NO: 125903-81-3
• Molecular Formula: C₈H₈F₂O₂
• Molecular Weight: 174.14
• Mol File: 125903-81-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 242.2 °C at 760 mmHg
• Flash Point: 118.9 °C
• Appearance: /
• Density: 1.257 g/cm³
• Vapor Pressure: 0.0185mmHg at 25°C
• Refractive Index: 1.484
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-(DIFLUOROMETHOXY)BENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(DIFLUOROMETHOXY)BENZYL ALCOHOL(125903-81-3)
• EPA Substance Registry System: 3-(DIFLUOROMETHOXY)BENZYL ALCOHOL(125903-81-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 125903-81-3(Hazardous Substances Data)

Usage

General Description

3-(Difluoromethoxy)benzyl alcohol is an organic compound with the molecular formula C8H8F2O2. It is a benzyl alcohol derivative with two fluorine atoms attached to a methoxy group. This chemical compound is commonly used as a reagent in organic synthesis and it is also used as a pharmaceutical intermediate. It is a colorless liquid with a faint aromatic odor and it is known for its low toxicity and high stability, making it an important component in various chemical reactions and processes.

InChI:InChI=1/C8H8F2O2/c9-8(10)12-7-3-1-2-6(4-7)5-11/h1-4,8,11H,5H2

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 85684-61-3 3-(difluoromethoxy)-benzaldehyde 
• 75-45-6 Chlorodifluoromethane 
• 620-24-6 3-Hydroxybenzyl alcohol 

Downstream Products

• 438047-64-4 3-Difluoromethoxybenzyl cis-2,6-dimethylpiperazine-1-carboxylate fumarate 
• 97603-96-8 3-Difluoromethoxy-benzamidine; hydrochloride 
• 97603-92-4 3-Difluoromethoxy-benzaldehyde oxime 
• 97582-88-2 3-(Difluoromethoxy)benzonitrile 
• 85684-61-3 3-(difluoromethoxy)-benzaldehyde 

Relevant articles and documents

IMIDAZOLIDINONE DERIVATIVES AS INHIBITORS OF PERK

The invention is directed to substituted imidazolidinone derivatives. Specifically, the invention is directed to compounds according to Formula I (I) wherein R1, R2, R3, R4, R5, R6, R7, X, Y1, Y2 and Z are defined herein. The compounds of the invention are inhibitors of PERK and can be useful in the treatment of cancer, pre-cancerous syndromes, as Alzheimer's disease, neuropathic pain, spinal cord injury, traumatic brain injury, ischemic stroke, stroke, Parkinson disease, diabetes, metabolic syndrome, metabolic disorders, Huntington's disease, Creutzfeldt-Jakob Disease, fatal familial insomnia, Gerstmann-Str?ussler-Scheinker syndrome, and related prion diseases, amyotrophic lateral sclerosis, progressive supranuclear palsy, myocardial infarction, cardiovascular disease, inflammation, organ fibrosis, chronic and acute diseases of the liver, fatty liver disease, liver steatosis, liver fibrosis, chronic and acute diseases of the lung, lung fibrosis, chronic and acute diseases of the kidney, kidney fibrosis, chronic traumatic encephalopathy (CTE), neurodegeneration, dementias, frontotemporal dementias, tauopathies, Pick's disease, Neimann-Pick's disease, amyloidosis, cognitive impairment, atherosclerosis, ocular diseases, arrhythmias, in organ transplantation and in the transportation of organs for transplantation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PERK activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.