1259283-25-4Relevant articles and documents
Total syntheses of tubulysins
Shibue, Taku,Hirai, Toshihiro,Okamoto, Iwao,Morita, Nobuyoshi,Masu, Hyuma,Azumaya, Isao,Tamura, Osamu
experimental part, p. 11678 - 11688 (2010/11/18)
The total syntheses of tetrapeptides tubulysins D (1b), U (1c), and V (1d), which are potent tubulin polymerization inhibitors, are described. The synthesis of Tuv (2), an unusual amino acid constituent of tubulysins, includes an 1,3-dipolar cycloaddition