1259436-57-1

Basic information

• Product Name: (R)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide
• Synonyms: (R)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide
• CAS NO: 1259436-57-1
• Molecular Weight: 259.329
• Mol File: 1259436-57-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide(1259436-57-1)
• EPA Substance Registry System: (R)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide(1259436-57-1)

Safety Data

• Hazardous Substances Data: 1259436-57-1(Hazardous Substances Data)

Upstream product

• 5669-05-6 1,2-benzoisothiazole 1,1-dioxide 
• 5720-05-8 4-methylphenylboronic acid 
• 38938-54-4 3-(4-methylphenyl)-1,2-benzoisothiazole 1,1-dioxide 
• 104-87-0 4-methyl-benzaldehyde 
• 1009806-74-9 N-t-butyl-2-[1-(4-methylphenyl)-1-hydroxymethyl]benzenesulfonamide 
• 2512-24-5 N-tert-butylbenzenesulfonamide 

Relevant articles and documents

Ni(II)/tBu-SMI-PHOX catalyzed enantioselective addition of arylboronic acids to cyclic N-sulfonyl aldimines

An efficient Ni(ClO4)2·6H2O/SMI-PHOX catalyzed enantioselective addition of arylboronic acids to cyclic N-sulfonyl aldimines is envisioned to afford excellent enantioselectivities (up to 99% ee) in high yields (up to 98%). This protocol offers new opportunities for the synthesis of chiral benzosultams containing a stereogenic tertiary carbon center. The highlights of this method include mild reaction conditions, the use of cheap metal catalyst and a wide substrate scope.

Synthesis of chiral sultams via palladium-catalyzed intramolecular asymmetric reductive amination

A novel palladium-catalyzed intramolecular reductive amination of ketones with weakly nucleophilic sulfonamides has been developed in the presence of a Br?nsted acid, giving a wide range of chiral γ-, δ-, and ε-sultams in high yields and up to 99% of enan