1259933-16-8

Basic information

• Product Name: XEN402
• Synonyms: XEN402;Funapide;(7S)-1′-{[5-(trifluoromethyl)furan-2-yl]methyl}spiro[furo[2,3-f][1,3]benzodioxole-7,3′-indol]-2′(1′H)-one;(3'S)-1'-[[5-(Trifluoromethyl)-2-furanyl]methyl]spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3'-[3H]indol]-2'(1'H)-one;Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3'-[3H]indol]-2'(1'H)-one,1'-[[5-(trifluoromethyl)-2-furanyl]methyl]-,(3'S)-
• CAS NO: 1259933-16-8
• Molecular Formula: C22H14F3NO5
• Molecular Weight: 429.35
• EINECS: -0
• Mol File: 1259933-16-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 612.2±55.0 °C(Predicted)
• Appearance: /
• Density: 1.59±0.1 g/cm3(Predicted)
• PKA: -0.53±0.20(Predicted)
• CAS DataBase Reference: XEN402(CAS DataBase Reference)
• NIST Chemistry Reference: XEN402(1259933-16-8)
• EPA Substance Registry System: XEN402(1259933-16-8)

Safety Data

• Hazardous Substances Data: 1259933-16-8(Hazardous Substances Data)

Usage

Description

XEN402 is a small-molecule inhibitor of the sodium channel Nav1.7 and other sodium channels, including those expressed in the pain-sensing peripheral nervous system. It has potentially broad application in nociceptive pain, including inflammatory pain and neuropathic pain indications.

Uses

Used in Pain Management:
XEN402 is used as a pain management agent for the treatment of inflammatory pain and neuropathic pain. It works by inhibiting the sodium channel Nav1.7 and other sodium channels in the pain-sensing peripheral nervous system, thereby reducing pain signals and providing relief to patients.
Used in Pharmaceutical Industry:
XEN402 is used as a drug candidate in the pharmaceutical industry for the development of novel pain management therapies. Its broad application in nociceptive pain makes it a promising candidate for the treatment of various pain conditions, offering new treatment options for patients suffering from chronic and acute pain.

Upstream product

• 1467104-83-1 (3S)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3-(hydroxymethyl)-1-{[5-(trifluoromethyl)furan-2-yl]methyl}-1,3-dihydro-2H-indol-2-one 
• 17515-77-4 2-(bromomethyl)-5-(trifluoromethyl)furan 
• 533-31-3 Sesamol 
• 1467104-92-2 (3S)-1-(diphenylmethyl)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3-(hydroxymethyl)-1,3-dihydro-2H-indol-2-one 
• 1467104-94-4 (7S)-spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one 
• 1467104-91-1 (3S)-3-[6-(benzyloxy)-1,3-benzodioxol-5-yl]-3-[(benzyloxy)methyl]-1-(diphenylmethyl)-1,3-dihydro-2H-indol-2-one 
• 1467104-90-0 3-[6-(benzyloxy)-1,3-benzodioxol-5-yl]-1-(diphenylmethyl)-1,3-dihydro-2H-indol-2-one 
• 91-56-5 indole-2,3-dione 
• 1467104-89-7 3-[6-(benzyloxy)-1,3-benzodioxol-5-yl]-1-(diphenylmethyl)-3-hydroxy-1,3-dihydro-2H-indol-2-one 
• 94878-41-8 1-(diphenylmethyl)-1H-indole-2,3-dione 
• 1467104-87-5 (3S)-3-[6-(benzyloxy)-1,3-benzodioxol-5-yl]-3-[(benzyloxy)methyl]-1-{[5-(trifluoromethyl)furan-2-yl]methyl}-1,3-dihydro-2H-indol-2-one 
• 1467104-82-0 3-[6-(benzyloxy)-1,3-benzodioxol-5-yl]-1-{[5-(trifluoromethyl)furan-2-yl]methyl}-1,3-dihydro-2H-indol-2-one 
• 1467104-81-9 3-[6-(benzyloxy)-1,3-benzodioxol-5-yl]-3-hydroxy-1-{[5-(trifluoromethyl)furan-2-yl]methyl}-1,3-dihydro-2H-indol-2-one 
• 1467104-79-5 3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1-{[5-(trifluoromethyl)furan-2-yl]methyl}-1,3-dihydro-2H-indol-2-one 

Relevant articles and documents

ASYMMETRIC SYNTHESIS OF FUNAPIDE

This invention is directed to asymmetric synthesis of funapide, which is useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Preparation of chiral 3-aryl-3-hydroxymethyl-2-indolone compounds

The invention relates to a preparation method of chiral 3-aryl-3-hydroxymethyl-2-indolone compounds representing by formula IV and formula V. The reaction process is also disclosed in the invention.

ASYMMETRIC SYNTHESES FOR SPIRO-OXINDOLE COMPOUNDS USEFUL AS THERAPEUTIC AGENTS

This invention is directed to asymmetric syntheses of certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.