1260029-44-4 Usage
Description
(E)-4-(2,4,5-trifluoro-phenyl)-but-2-enoic acid methyl ester is a chemical compound with the molecular formula C11H9F3O2. It is a methyl ester derivative of butenoic acid, featuring a unique trifluorophenyl group that contributes to its distinct properties and applications.
Uses
Used in Organic Synthesis:
(E)-4-(2,4,5-trifluoro-phenyl)-but-2-enoic acid methyl ester is used as a reagent in organic synthesis for the creation of various drug compounds and agrochemicals. Its trifluorophenyl group enhances the biological and pharmacokinetic properties of potential drug candidates, making it a valuable building block in the development of new molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (E)-4-(2,4,5-trifluoro-phenyl)-but-2-enoic acid methyl ester serves as a key building block for the synthesis of drug compounds. Its unique structural features allow researchers to modify and optimize the properties of drug candidates, potentially leading to more effective and safer medications.
Used as a Reference Standard in Analytical Chemistry:
(E)-4-(2,4,5-trifluoro-phenyl)-but-2-enoic acid methyl ester is also utilized as a reference standard in analytical chemistry. It aids in the identification and quantification of (E)-4-(2,4,5-trifluoro-phenyl)-but-2-enoic acid and related compounds in various samples, ensuring accurate and reliable results in chemical analysis.
Check Digit Verification of cas no
The CAS Registry Mumber 1260029-44-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,0,0,2 and 9 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1260029-44:
(9*1)+(8*2)+(7*6)+(6*0)+(5*0)+(4*2)+(3*9)+(2*4)+(1*4)=114
114 % 10 = 4
So 1260029-44-4 is a valid CAS Registry Number.
1260029-44-4Relevant articles and documents
D-Glucosamine in iron-catalysed cross-coupling reactions of Grignards with allylic and vinylic bromides: Application to the synthesis of a key sitagliptin precursor
Sova, Matej,Frlan, Rok,Gobec, Stanislav,Stavber, Gaj,asar, Zdenko
, p. 528 - 535 (2015/08/04)
A sustainable D-glucosamine ligand is successfully introduced into iron-catalysed C-C cross-coupling reactions for the first time. The Fe(acac)2/D-glucosamine·HCl/Et3N catalytic system was effective at 5 mol% loading in coupling reactions of Grignard reagents with organic bromides. Moderate to high efficiency was achieved with preserved stereochemistry when allyl (Csp3) or alkenyl (Csp2) bromides were coupled with phenylmagnesium (Csp2) or benzylmagnesium (Csp3) bromides. The catalytic system developed was also successfully applied for the novel and economic preparation of a Michael-acceptor-like starting material used in an alternative synthesis of the drug sitagliptin, a known blockbuster for the treatment of type II diabetes mellitus.
PREPARATION OF SITAGLIPTIN INTERMEDIATES
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Paragraph 0275; 0276, (2014/07/08)
The invention relates to the preparation of chiral compounds, in particular to the preparation of chiral compounds which may be used as intermediates for the preparation of anti-diabetic agents, preferably sitagliptin.
PREPARATION OF SITAGLIPTIN INTERMEDIATES
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Page/Page column 20, (2013/02/28)
The invention relates to the preparation of chiral compounds, in particular to the preparation of chiral compounds which may be used as intermediates for the preparation of anti-diabetic agents, preferably sitagliptin.
