1260072-60-3Relevant articles and documents
Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates
Topalis, Dimitri,Pradère, Ugo,Roy, Vincent,Caillat, Christophe,Azzouzi, Ahmed,Broggi, Julie,Snoeck, Robert,Andrei, Graciela,Lin, Jay,Eriksson, Staffan,Alexandre, Julie A. C.,El-Amri, Chahrazade,Deville-Bonne, Dominique,Meyer, Philippe,Balzarini, Jan,Agrofoglio, Luigi A.
, p. 222 - 232 (2011/03/22)
Acyclic nucleoside phosphonates (ANPs) are at the cornerstone of DNA virus and retrovirus therapies. They reach their target, the viral DNA polymerase, after two phosphorylation steps catalyzed by cellular kinases. New pyrimidine ANPs have been synthesize