1260403-64-2

Basic information

• Product Name: 4-(3,5-difluorophenyl)-5H-[1,2,3]-oxathiazole 2,2-dioxide
• Synonyms: 4-(3,5-difluorophenyl)-5H-[1,2,3]-oxathiazole 2,2-dioxide
• CAS NO: 1260403-64-2
• Molecular Weight: 233.195
• Mol File: 1260403-64-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(3,5-difluorophenyl)-5H-[1,2,3]-oxathiazole 2,2-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3,5-difluorophenyl)-5H-[1,2,3]-oxathiazole 2,2-dioxide(1260403-64-2)
• EPA Substance Registry System: 4-(3,5-difluorophenyl)-5H-[1,2,3]-oxathiazole 2,2-dioxide(1260403-64-2)

Safety Data

• Hazardous Substances Data: 1260403-64-2(Hazardous Substances Data)

Upstream product

• 1260403-62-0 α-hydroxy-3,5-difluoroacetophenone 
• 1260403-63-1 α-acetoxy-3,5-difluoroacetophenone 
• 461-96-1 3,5-difluorobromobenzene 

Downstream Products

• 957121-89-0 ethyl [(8R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate 
• 957118-49-9 [3H]-MK 3207 
• 1260403-65-3 C₈H₇F₂NO₃S 
• 1260403-66-4 C₁₅H₂₀F₂N₂O₅S 
• 1260403-67-5 C₁₄H₁₆F₂N₂O 
• 957187-34-7 C₁₆H₁₈F₂N₂O₃ 
• 1212932-15-4 (S)-2-amino-2-(3,5-difluorophenyl)ethanol 

Relevant articles and documents

Enantioselective Access to Chiral Cyclic Sulfamidates Through Iridium-Catalyzed Asymmetric Hydrogenation

The Iridium-catalyzed asymmetric hydrogenation of cyclic sulfamidate imines was successfully developed with N-methylated ZhaoPhos L2 as the ligand. A variety of chiral cyclic sulfamidates were obtained with excellent results (up to 99% yield, 99% ee). Furthermore, this asymmetric hydrogenation can be employed as the key reaction step to prepare the important intermediates in organic synthesis. (Figure presented.).

PROCESS FOR MAKING CGRP RECEPTOR ANTAGONIST

The invention encompasses a novel process for making 2-[(8R)-8-(3,5-Difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]-N-[(2R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl]acetamide, which is a CGRP receptor antagonist useful for the treatment of migraine, using an asymmetric phase-transfer catalysis route. The invention also encompasses an efficient and practical synthesis of the (R)-acid intermediate, and generates the benzylic stereocenter in an enantioselective manner.