1260900-61-5

Basic information

• Product Name: C₁₅H₁₁NO₂
• CAS NO: 1260900-61-5
• Molecular Weight: 237.258
• Mol File: 1260900-61-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₁NO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₁NO₂(1260900-61-5)
• EPA Substance Registry System: C₁₅H₁₁NO₂(1260900-61-5)

Safety Data

• Hazardous Substances Data: 1260900-61-5(Hazardous Substances Data)

Upstream product

• 1670-82-2 Indole-6-carboxylic acid 
• 591-50-4 iodobenzene 

Relevant articles and documents

Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors

Selective inhibition of the aspartyl protease renin has gained attraction as an interesting approach to control hypertension and associated cardiovascular risk factors given its unique position in the renin-angiotensin system. Using a combination of high-throughput screening, parallel synthesis, X-ray crystallography and structure-based design, we identified and optimized a novel series of potent and non-chiral indole-3-carboxamides with remarkable potency for renin. The most potent compound 5k displays an IC50 value of 2 nM.