1261153-04-1

Basic information

• Product Name: (E)-5-fluoro-3-[[4-(methylsulfonyl)phenyl]methylene]indolin-2-one
• Synonyms: (E)-5-fluoro-3-[[4-(methylsulfonyl)phenyl]methylene]indolin-2-one
• CAS NO: 1261153-04-1
• Molecular Weight: 317.341
• Mol File: 1261153-04-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-5-fluoro-3-[[4-(methylsulfonyl)phenyl]methylene]indolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-5-fluoro-3-[[4-(methylsulfonyl)phenyl]methylene]indolin-2-one(1261153-04-1)
• EPA Substance Registry System: (E)-5-fluoro-3-[[4-(methylsulfonyl)phenyl]methylene]indolin-2-one(1261153-04-1)

Safety Data

• Hazardous Substances Data: 1261153-04-1(Hazardous Substances Data)

Upstream product

• 371-40-4 4-fluoroaniline 
• 351-09-7 N-(4-fluorophenyl)-2-(hydroxyimino) acetamide 
• 443-69-6 5-fluoro-1H-indole-2,3-dione 
• 1261152-93-5 C₈H₅FN₂O 
• 56341-41-4 5-fluoroindol-2(3H)-one 
• 5398-77-6 para-methanesulfonylbenzaldehyde 

Relevant articles and documents

Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl] methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors

Fourteen new 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives were synthesized. Six compounds displayed potent inhibitory activities against COX-1/2 and 5-LOX with IC50 in the range of 0.10-9.87 μM. Particularly, 10f exhibited well balanced inhibitory action on these enzymes (IC50 = 0.10-0.56 μM). More importantly, 10f and several other compounds had comparable or stronger anti-inflammatory and analgesic activities, but better gastric tolerability in vivo, as compared with darbufelone mesilate and tenidap sodium. Therefore, our findings may aid in the design of new and safe anti-inflammatory reagents for the intervention of painful inflammatory diseases, such as rheumatoid arthritis at clinic.