1262136-18-4

Basic information

• Product Name: 1-ethenyl-6,8-difluoro-7-(2-fluorophenyl-1-piperazinyl)-4(1H)-oxoquinoline-3-carboxylic acid
• CAS NO: 1262136-18-4
• Molecular Weight: 431.414
• Mol File: 1262136-18-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-ethenyl-6,8-difluoro-7-(2-fluorophenyl-1-piperazinyl)-4(1H)-oxoquinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ethenyl-6,8-difluoro-7-(2-fluorophenyl-1-piperazinyl)-4(1H)-oxoquinoline-3-carboxylic acid(1262136-18-4)
• EPA Substance Registry System: 1-ethenyl-6,8-difluoro-7-(2-fluorophenyl-1-piperazinyl)-4(1H)-oxoquinoline-3-carboxylic acid(1262136-18-4)

Safety Data

• Hazardous Substances Data: 1262136-18-4(Hazardous Substances Data)

Upstream product

• 75338-42-0 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 

Relevant articles and documents

Synthesis and in vitro antimicrobial evaluation of novel fluoroquinolone derivatives

A series of 1-ethyl-6,8-difluoro-4-oxo-7(4-aryl piperazin-1-yl) 1,4-dihydro-quinoline-3-carboxylic acid derivatives (6a-f) and 1-ethyl-6,8-difluoro-4-oxo-7(4-piperidin-1-yl) 1,4-dihydro-quinoline-3- carboxylic acid derivatives (7a-e) were synthesized and evaluated for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by the microbroth dilution technique. The compounds were also evaluated for antifungal activity against Candida albicans (ATCC 90028) and Cryptococcous neoformans (ATCC 14116) pathogens. The preliminary in vitro evaluation studies revealed that some of the compounds have promising antimicrobial activities.