1262217-03-7

Basic information

• Product Name: (2S,3S)-3-(1-adamantyl)-3-(tert-butoxycarbonylamino)-1,2-O-isopropylidene-1,2-propanediol
• CAS NO: 1262217-03-7
• Molecular Weight: 365.513
• Mol File: 1262217-03-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3S)-3-(1-adamantyl)-3-(tert-butoxycarbonylamino)-1,2-O-isopropylidene-1,2-propanediol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-3-(1-adamantyl)-3-(tert-butoxycarbonylamino)-1,2-O-isopropylidene-1,2-propanediol(1262217-03-7)
• EPA Substance Registry System: (2S,3S)-3-(1-adamantyl)-3-(tert-butoxycarbonylamino)-1,2-O-isopropylidene-1,2-propanediol(1262217-03-7)

Safety Data

• Hazardous Substances Data: 1262217-03-7(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1262217-02-6 (2S,3S)-3-(1-adamantyl)-3-(N-benzylhydroxylamino)-1,2-O-isopropylidene-1,2-propanediol 

Relevant articles and documents

Synthesis of adamantylglycine using a diastereoselective grignard-to-nitrone addition

In contrast to amino acids with a bulky substituent like tert-leucine, adamantylglycine has so far received little attention. Here, a new, practical synthesis of adamantylglycine is described. This is based on a highly diastereoselective addition of adamantyl Grignard reagent to 2,3-O-cyclohexylideneglyceraldehyde N-benzylnitrone, mediated by the Lewis acid diethylaluminum chloride. Adamantylglycine is obtained from the nitrone in 6 steps and 28% yield as a crystalline hydrochloride with 0.5 methanol incorporated.