1262310-96-2

Basic information

• Product Name: 5'-O-(4,4'-dimethoxytrityl)-N₂-benzyl-8-oxo-7,8-dihydro-2'-deoxyguanosine
• Synonyms: 5'-O-(4,4'-dimethoxytrityl)-N₂-benzyl-8-oxo-7,8-dihydro-2'-deoxyguanosine
• CAS NO: 1262310-96-2
• Molecular Weight: 675.741
• Mol File: 1262310-96-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5'-O-(4,4'-dimethoxytrityl)-N₂-benzyl-8-oxo-7,8-dihydro-2'-deoxyguanosine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4,4'-dimethoxytrityl)-N₂-benzyl-8-oxo-7,8-dihydro-2'-deoxyguanosine(1262310-96-2)
• EPA Substance Registry System: 5'-O-(4,4'-dimethoxytrityl)-N₂-benzyl-8-oxo-7,8-dihydro-2'-deoxyguanosine(1262310-96-2)

Safety Data

• Hazardous Substances Data: 1262310-96-2(Hazardous Substances Data)

Upstream product

• 96964-90-8 8-(benzyloxy)-2'-deoxyguanosine 
• 13389-03-2 8-bromo-2'-deoxyguanosine 
• 88847-89-6 7,8-dihydro-8-oxo-2'-deoxyguanosine 
• 961-07-9 2'-Deoxyguanosine 
• 1262310-95-1 N₂-benzyl-8-oxo-7,8-dihydro-2'-deoxyguanosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Downstream Products

• 1262310-97-3 3'-O-[(diisopropylamino)-(2-cyanoethoxy)phosphino]-5'-O-(4,4'-dimethoxytrityl)-N₂-benzyl-8-oxo-7,8-dihydro-2'-deoxyguanosine 

Relevant articles and documents

Synthesis of N 2-Alkyl-8-oxo-7,8-dihydro-2′-deoxyguanosine derivatives and effects of these modifications on RNA duplex stability

N2-Alkyl analogues of 8-oxo-7,8-dihydro-2′-deoxyguanosine (OG) were synthesized (alkyl = propyl, benzyl) via reductive amination of the protected OG nucleoside and incorporated into various positions of an RNA strand. Thermal stability studies of duplexes containing A or C opposite a single modified base revealed only moderate destabilization. Both OG as well as its N2-alkyl analogues can pair opposite A or C with nearly equal stability, potentially offering a new means of modulating RNA-protein interactions in the minor vs major grooves.