1262854-85-2

Basic information

• Product Name: C₁₅H₁₆N₂O₂S
• Synonyms: C₁₅H₁₆N₂O₂S
• CAS NO: 1262854-85-2
• Molecular Weight: 288.37
• Mol File: 1262854-85-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₆N₂O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₆N₂O₂S(1262854-85-2)
• EPA Substance Registry System: C₁₅H₁₆N₂O₂S(1262854-85-2)

Safety Data

• Hazardous Substances Data: 1262854-85-2(Hazardous Substances Data)

Upstream product

• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 34079-31-7 Z-Pro-NH₂ 
• 63808-47-9 Cbz-L-proline thioamide 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 107-20-0 2-chloroethanal 

Relevant articles and documents

Total syntheses of smenothiazoles A and B

Concise total syntheses of smenothiazoles A (1) and B (2), two distinguished vinyl chloride containing natural products isolated from the marine sponge S. aurea, have been developed. Silastannation, Stille reaction and a carefully controlled desilylchlorination were employed as key steps to construct unique polyketide acid fragments, and the optimized reaction conditions avoided migration of 2,5-diene to a 2,4-conjugated system. This report unambiguously confirmed the structures of both natural products.

Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers

Design and synthesis of pyrazolodihydropyrimidines as KV1.5 blockers led to the discovery of 7d as a potent and selective antagonist. This compound showed atrial selective prolongation of effective refractory period in rabbits and was selected for clinical development.