1262985-25-0

Basic information

• Product Name: 4-(2-amino-5-bromo-pyridin-3-yl)-2-methyl-but-3-yn-2-o
• Synonyms: 4-(2-amino-5-bromo-pyridin-3-yl)-2-methyl-but-3-yn-2-o;4-(2-amino-5-bromo-pyridin-3-yl)-2-methyl-but-3-yn-2-ol;4-(2-Amino-5-bromo-3-pyridinyl)-2-methyl-3-butyn-2-ol
• CAS NO: 1262985-25-0
• Molecular Formula: C₁₀H₁₁BrN₂O
• Molecular Weight: 255.11114
• EINECS: -0
• Mol File: 1262985-25-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(2-amino-5-bromo-pyridin-3-yl)-2-methyl-but-3-yn-2-o(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-amino-5-bromo-pyridin-3-yl)-2-methyl-but-3-yn-2-o(1262985-25-0)
• EPA Substance Registry System: 4-(2-amino-5-bromo-pyridin-3-yl)-2-methyl-but-3-yn-2-o(1262985-25-0)

Safety Data

• Hazardous Substances Data: 1262985-25-0(Hazardous Substances Data)

Upstream product

• 1072-97-5 5-bromo-2-pyridylamine 
• 381233-96-1 2-amino-3-iodo-5-bromopyridine 
• 115-19-5 2-methyl-but-3-yn-2-ol 

Downstream Products

• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 
• 1210838-82-6 5-bromo-3-ethynyl-pyridin-2-ylamine 

Relevant articles and documents

Preparation method for 5-bromo-7-azindole

The invention belongs to the technical field of preparation of 5-bromo-7-azindole, in particular to a preparation method for the 5-bromo-7-azindole. The method comprises the following steps: taking 2-amino-5-bromopyridine as a raw material, and performing the steps in sequence: (1) introducing iodine through an iodine reagent; (2) performing a coupling reaction with methylbutynol; and (3) performing a ring-closing reaction under the catalysis of inorganic strong base to prepare the 5-bromo-7-azindole, wherein the catalyst adopted in the coupling reaction in the step (2) is bis(benzonitrile)palladium dichloride or [1,1'-bis(diphenylphosphine)ferrocene]palladium dichloromethane dichloride complex compound. According to the preparation method, cheap 2-amino-5-bromopyridine is taken as the rawmaterial in the step (1); the catalyst with high catalyzing efficiency and a solvent which is easy to treat are adopted; purifying steps in each step are simple; the yield is high; and the and the yield of the finally prepared product, namely, the 5-bromo-7-azindole, can reach over 93 percent.