12634-43-4

Basic information

• Product Name: SPECTRIN
• Synonyms: SPECTRIN;spectrin from human erythrocytes;brain 1;non-erythroid β chain 1;Spectrin β chain;β-II spectrin
• CAS NO: 12634-43-4
• Molecular Formula: MW:
• Molecular Weight: 0
• Product Categories: Serum ProteinsPlasma&Blood Proteins;SpectrinProteins and Derivatives;Application Index;Plasma, Blood, and Related Proteins and Reagents;Serum Proteins and Related Enzymes;Spectrin;Structural Proteins
• Mol File: 12634-43-4.mol
• Article Data: 0

Chemical Properties

• Appearance: /buffered aqueous glycerol solution
• Storage Temp.: −20°C
• CAS DataBase Reference: SPECTRIN(CAS DataBase Reference)
• NIST Chemistry Reference: SPECTRIN(12634-43-4)
• EPA Substance Registry System: SPECTRIN(12634-43-4)

Safety Data

• Hazard Codes: B
• WGK Germany: 3
• Hazardous Substances Data: 12634-43-4(Hazardous Substances Data)

Usage

Description

SPECTRIN is a protein found in the cytoskeleton of cells, particularly in red blood cells. It plays a crucial role in maintaining the structural integrity and shape of these cells. The C-terminus of spectrin contains a calmodulin-like EF domain, which is essential for its binding to actin, thus facilitating proper cytoskeletal formation. The deletion of this domain can lead to the formation of weak and irregularly-shaped red blood cells.

Uses

1. Used in Medical Research:
SPECTRIN is used as a research tool for studying the structure and function of the cytoskeleton in cells, particularly red blood cells. Its role in maintaining cell shape and integrity makes it a valuable subject for understanding various cellular processes and potential therapeutic applications.
2. Used in Diagnostics:
SPECTRIN can be utilized in diagnostic applications to identify and study abnormalities in red blood cell shape and function. This can be particularly useful in the detection and monitoring of various blood disorders and anemias.
3. Used in Drug Development:
Understanding the role of SPECTRIN in the cytoskeleton can aid in the development of drugs targeting the cytoskeleton for the treatment of various diseases, including blood disorders and conditions affecting cell shape and integrity.
4. Used in Cell Biology Education:
SPECTRIN serves as an important example in cell biology education, helping students understand the complex interactions between proteins and other cellular components that contribute to the overall structure and function of cells.