126378-11-8Relevant articles and documents
The synthesis of corticosteroid-carborane esters for the treatment of rheumatoid arthritis via boron neutron capture synovectomy
Valliant, John F.,Schaffer, Paul,Britten, James F.,Davison, Alan,Jones, Alun G.,Yanch, Jacquelyn C.
, p. 1355 - 1358 (2000)
Two corticosteroid-carborane esters were synthesized through the use of a BOP-Cl promoted esterification. The steroid-carborane conjugates are designed to selectively deliver boron to arthritic tissue for boron neutron capture synovectomy, a new therapeut
NOVEL LYSOPHOSPHATIDIC ACID DERIVATIVE
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Paragraph 0519-0521, (2021/05/28)
PROBLEM TO BE SOLVED: To provide a compound that specifically activates an LPA4 receptor, and a pharmaceutical composition containing the same. SOLUTION: This invention relates to a novel lysophosphatidic acid derivative that has an agonistic action on an LPA4 receptor and is useful for the prevention and/or treatment of a disease with angiodysplasia caused by the LPA4 receptor, or a disease associated with angiopathy, or symptoms associated therewith. This invention also relates to a pharmaceutical composition containing the lysophosphatidic acid derivative. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
GOLD (I)-PHOSPHINE 1,2,3-TRIAZOLE DERIVATIVES WITH ANTIOBIOTIC PROPERTIES
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Page/Page column 35-36, (2020/01/11)
The present invention relates to gold (l)-phosphine 1,2,3-triazole compounds, and their use in a human or animal medicine. The present invention also relates to using such compounds for the prevention and/or treatment of an infection, i.e. inhibitors of growth of Gram-positive and/or Gram-negative bacteria. On another aspect the invention relates to the synthesis of the gold (l)-phosphine compounds of the invention and to their synthesis intermediates. The present invention finds applications in the medical, veterinary and/or chemical fields.