126402-81-1

Basic information

• Product Name: isopropyl 2-[(E)-1-phenylmethylideneamino]propanoate
• Synonyms: isopropyl 2-[(E)-1-phenylmethylideneamino]propanoate
• CAS NO: 126402-81-1
• Molecular Weight: 219.283
• Mol File: 126402-81-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: isopropyl 2-[(E)-1-phenylmethylideneamino]propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: isopropyl 2-[(E)-1-phenylmethylideneamino]propanoate(126402-81-1)
• EPA Substance Registry System: isopropyl 2-[(E)-1-phenylmethylideneamino]propanoate(126402-81-1)

Safety Data

• Hazardous Substances Data: 126402-81-1(Hazardous Substances Data)

Upstream product

• 39825-33-7 isopropyl ester of alanine 
• 100-52-7 benzaldehyde 
• 39613-92-8 alanine isopropyl ester hydrochloride 
• 120328-90-7 methyl (E)-N-benzylidenealaninate 

Relevant articles and documents

Metal-dependent stereochemistry of C - C bond formation under the asymmetric phase transfer catalysis by chiral salen complexes

The effect of the nature of the central metal atom in chiral salen type complexes on the stereodifferentiating capacity of these complexes as catalysts in phase transfer asymmetric alkylation of Schiff's base derived from alanine isopropyl ester and benzaldehyde by benzyl bromide. The nature of the central metal atom in the complex has a pronounced influence on the stereochemistry of alkylation; copper(II) complexes exhibit the highest activity combined with a high stereoselectivity.

NOVEL CRYSTAL MODIFICATIONS

Novel crystal modifications of (5S)-5-[4-(5-chloro-pyridin-2-yloxy)-piperidine-1-sulfonylmethyl]-5-methyl-imidazolidine-2,4-dione are disclosed together with processes for preparing such modifications, pharmaceutical compositions comprising such a modification, and the use of such a modification in therapy.

The effect of phase-transfer catalysis in the 1,3-dipolar cycloaddition reactions of azomethine ylides - Synthesis of substituted prolines using AgOAc and inorganic base in substoichiometric amounts

The 1,3-dipolar cycloaddition reaction between imino ester 1a and ethyl acrylate, employing phase-transfer catalysis (PTC) conditions in the presence of substoichiometric amounts of Lewis acids and inorganic bases, has been studied for the first time. Effects were analysed in the order: solvent, phase transfer agent, inorganic base, metal salt (Lewis acid), quantity of metal salt and the substituents on the 1,3-dipole. The two best methods found in this study [method A: THF, TBAC (10 mol-%), KOH (10 mol-%), AgOAc (10 mol-%), room temp.; method B: toluene, KOH (10 mol-%), AgOAc (10 mol-%), room temp.] were then applied to the cycloaddition reaction of the imino esters 1a and 5a (derived from alanine and glycine) with alkenes. These results were compared to those obtained under thermal 1,3-dipolar cycloaddition reaction conditions and to those previously reported using metallodipoles in the presence of organic bases.