126451-47-6 Usage
Description
(S)-(+)-Manidipine, also known as (S)-Manidipine Hydrochloride, is the (S) stereoisomer of Manidipine, a dihydropyridine calcium channel blocker. It is characterized by its ability to block calcium channels, which leads to a reduction in blood pressure. This makes it a valuable compound in the field of pharmaceuticals, particularly for the treatment of hypertension.
Used in Pharmaceutical Industry:
(S)-(+)-Manidipine is used as an antihypertensive agent for the treatment of high blood pressure. Its mechanism of action involves blocking L-type calcium channels in vascular smooth muscle cells, leading to vasodilation and a decrease in peripheral vascular resistance. This results in a lowering of blood pressure, making it a beneficial medication for individuals suffering from hypertension.
Check Digit Verification of cas no
The CAS Registry Mumber 126451-47-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,6,4,5 and 1 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 126451-47:
(8*1)+(7*2)+(6*6)+(5*4)+(4*5)+(3*1)+(2*4)+(1*7)=116
116 % 10 = 6
So 126451-47-6 is a valid CAS Registry Number.
126451-47-6Relevant articles and documents
Preparation method of (S)-manidipine
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Paragraph 0064; 0065; 0066, (2016/10/20)
The invention relates to a preparation method of (S)-manidipine. Particularly, racemic manidipine free alkali is taken as a raw material, a resolving agent is used, and (S)-manidipine free alkali with optical activity is obtained with a chemical salting-out method. According to the preparation method, the yield is high, the process is simple to operate, the cost is lower, and (S)-manidipine is suitable for industrial production.
