12651-38-6Relevant articles and documents
Metal-Templated Macrolactamization of Triamino and Tetramino Esters. Facile Synthesis of Macrocyclic Spermidine and Spermine Alkaloids, (S)-(+)-Dihydroperiphylline, (±)-Buchnerine, (±)-Verbacine, (±)-Verbaskine, and (±)-Verbascenine
Kuroki, Yoshichika,Ishihara, Kazuaki,Hanaki, Naoyuki,Ohara, Suguru,Yamamoto, Hisashi
, p. 1221 - 1230 (2007/10/03)
The total synthesis of spermidine and spermine alkaloids. (S)-(+)-dihydroperiphylline (1), (±)-buchnerine (2), (±)-verbacine (3), (±)-verbaskine (4), and (±)-verbascenine (5), is described. The construction of macrocyclic lactams has been efficiently accomplished by the metal-templated cyclization of triamino esters and tetraamino esters. It was also found that the antimony(III) ethoxide is useful as an intermolecular amidation catalyst.
Verbacine and Verballocine, Novel Macrocyclic Spermine Alkaloids from Verbascum pseudonobile Stoj. et Stef. (Scrophulariaceae)
Drandarov, Konstantin
, p. 617 - 620 (2007/10/02)
The isolation and structural elucidation of the novel 17-membered lactam alkaloids verbacine (1) and verballocine (2) containing spermine, E- (or Z-)cinnamoyl and phenylpropionyl precursory units, is reported.Evidence for the artificial origin of the prev