126559-84-0

Basic information

• Product Name: 11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)
• Synonyms: 11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)
• CAS NO: 126559-84-0
• Molecular Weight: 496.69
• Mol File: 126559-84-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)(CAS DataBase Reference)
• NIST Chemistry Reference: 11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)(126559-84-0)
• EPA Substance Registry System: 11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)(126559-84-0)

Safety Data

• Hazardous Substances Data: 126559-84-0(Hazardous Substances Data)

Upstream product

• 129000-33-5 11β-vinylestrone 3-acetate 
• 68599-01-9 11beta-Vinylestradiol 
• 129000-34-6 11β-(1-ethenyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether) 

Downstream Products

• 1373113-09-7 C₃₆H₄₂O₄ 
• 849241-68-5 3,17β-dibenzyloxy-11β-(2-propoxyethyl)estra-1,3,5(10)-triene 
• 849241-67-4 3,17β-dibenzyloxy-11β-(2-ethoxyethyl)estra-1,3,5(10)-triene 
• 1373112-24-3 C₃₆H₄₂O₃ 
• 756844-19-6 3,17β-bis(benzyloxy)-11β-benzylthioethylestra-1,3,5(10)-triene 
• 756844-23-2 (8S,9S,11R,13S,14S,17S)-11-(2-Benzylsulfanyl-ethyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol 
• 849241-49-2 1-(3,17β-dibenzyloxyestra-1,3,5(10)-trien-11β-yl)hexan-3-one 
• 849241-47-0 1-(3,17β-dibenzyloxyestra-1,3,5(10)-trien-11β-yl)pentan-3-one 
• 849241-71-0 3,17β-dibenzyloxy-11β-(2-(2-fluoroethoxy)ethyl)estra-1,3,5(10)-triene 
• 849241-70-9 3,17β-dibenzyloxy-11β-(2-tert-butoxyethyl)estra-1,3,5(10)-triene 
• 849241-45-8 4-(3,17β-dibenzyloxyestra-1,3,5(10)-trien-11β-yl)butan-2-one 
• 849241-69-6 3,17β-dibenzyloxy-11β-(2-isopropoxyethyl)estra-1,3,5(10)-triene 
• 147250-14-4 3-(3,17β-dibenzyloxyestra-1,3,5(10)-trien-11β-yl)propanenitrile 
• 849241-66-3 3,17β-dibenzyloxy-11β-(2-methoxyethyl)estra-1,3,5(10)-triene 

Relevant articles and documents

Synthesis and Estrogen Receptor Binding of Novel 11β-Substituted Estra-1,3,5(10)-triene-3,17β-diols

As part of our program to develop estrogenic radioligands for use in nuclear medicine, a study was undertaken to investigate the effect of substituents on the receptor affinity of putative radiochemicals.In the study a synthetic strategy directed toward the introduction of an 11β-(fluoroethyl) substituent was devised.The target compound 9 was prepared via a five-step procedure starting from 11β-vinylestrone 3-acetate (4) in an overall 43percent yield.The final product and several analogues, 11β-ethyl-, -vinyl-, and (hydroxyethyl)estradiols (11, 5, and 12), were evaluated for their estrogen receptor binding affinity.The results indicate that the target compound and several 11β-substituted analogues possess relative binding affinities greater than of estradiol and its 16α-fluorinated derivatives.The manner in which the target compound 9 was prepared is amenable to use with 18F incorporation.

11beta-short chain substituted estradiol analogs and their use in the treatment of menopausal symptoms and estrogen sensitive cancer

The present invention relates to novel 11-β estradiol ester compounds and their use as locally active estrogens in the treatment of the symptomology of menopause and to treat estrogen sensitive cancers, including breast cancer.