1266084-49-4 Usage
General Description
6-Amino-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol is a chemical compound with the formula C9H12BNO2. It is a boronic acid derivative that contains a boron atom, a benzene ring, and an oxygen heterocycle. The compound is of interest in medicinal chemistry due to its potential as a building block for the synthesis of pharmaceuticals and agrochemicals. Boronic acids are known for their ability to form stable complexes with diols, making them valuable reagents in organic synthesis. This particular compound's unique structure may also give it specific biological activities or targeting capabilities in drug design and development. Further research into the properties and reactivity of 6-amino-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol could reveal its potential applications in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 1266084-49-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,6,0,8 and 4 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1266084-49:
(9*1)+(8*2)+(7*6)+(6*6)+(5*0)+(4*8)+(3*4)+(2*4)+(1*9)=164
164 % 10 = 4
So 1266084-49-4 is a valid CAS Registry Number.
1266084-49-4Relevant articles and documents
Synthesis and SAR of acyclic HCV NS3 protease inhibitors with novel P4-benzoxaborole moieties
Li, Xianfeng,Zhang, Suoming,Zhang, Yong-Kang,Liu, Yang,Ding, Charles Z.,Zhou, Yasheen,Plattner, Jacob J.,Baker, Stephen J.,Bu, Wei,Liu, Liang,Kazmierski, Wieslaw M.,Duan, Maosheng,Grimes, Richard M.,Wright, Lois L.,Smith, Gary K.,Jarvest, Richard L.,Ji, Jing-Jing,Cooper, Joel P.,Tallant, Matthew D.,Crosby, Renae M.,Creech, Katrina,Ni, Zhi-Jie,Zou, Wuxin,Wright, Jon
, p. 2048 - 2054 (2011/04/24)
We have synthesized and evaluated a new series of acyclic P4-benzoxaborole-based HCV NS3 protease inhibitors. Structure-activity relationships were investigated, leading to the identification of compounds 5g and 17 with low nanomolar potency in the enzymatic and cell-based replicon assay. The linker-truncated compound 5j was found to exhibit improved absorption and oral bioavailability in rats, suggesting that further reduction of molecular weight and polar surface area could result in improved drug-like properties of this novel series.
