126610-77-3

Basic information

• Product Name: (R)-2-(Boc-aMino)-2-phenylethyl 4-Methylbenzenesulfonate
• Synonyms: (R)-2-(Boc-aMino)-2-phenylethyl 4-Methylbenzenesulfonate
• CAS NO: 126610-77-3
• Molecular Weight: 391.488
• Mol File: 126610-77-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (R)-2-(Boc-aMino)-2-phenylethyl 4-Methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(Boc-aMino)-2-phenylethyl 4-Methylbenzenesulfonate(126610-77-3)
• EPA Substance Registry System: (R)-2-(Boc-aMino)-2-phenylethyl 4-Methylbenzenesulfonate(126610-77-3)

Safety Data

• Hazardous Substances Data: 126610-77-3(Hazardous Substances Data)

Usage

General Description

The compound "(R)-2-(Boc-aMino)-2-phenylethyl 4-Methylbenzenesulfonate" is a chemical compound with a specific stereochemistry and functional groups. It consists of a Boc-protected amino group attached to a phenylethyl group, with a 4-methylbenzenesulfonate group linked to the phenylethyl moiety. The Boc group provides protection for the amine functionality, while the 4-methylbenzenesulfonate group can serve as a leaving group in chemical reactions. (R)-2-(Boc-aMino)-2-phenylethyl 4-Methylbenzenesulfonate may be used in organic synthesis as a building block for the preparation of various complex molecules, particularly in the field of pharmaceuticals. It is important to handle and use this compound with caution, following appropriate safety protocols.

Upstream product

• 1068458-40-1 C₁₆H₂₇NO₃Si 
• 455-16-3 p-toluenesulfonyl fluoride 
• 126568-41-0 Benzyl-((1R,2S,3S)-4-benzyloxy-2,3-bis-methoxymethoxy-1-phenyl-butyl)-amine 
• 126568-43-2 Benzyl-((1R,2S,3S)-4-benzyloxy-2,3-dihydroxy-1-phenyl-butyl)-carbamic acid tert-butyl ester 
• 126568-42-1 (1R,2S,3S)-1-Benzylamino-4-benzyloxy-1-phenyl-butane-2,3-diol 
• 126610-76-2 Benzyl-((R)-2-hydroxy-1-phenyl-ethyl)-carbamic acid tert-butyl ester 
• 14231-57-3 (R)-N-benzyl-2-phenylglycinol 
• 56613-80-0 D-2-phenylglycinol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 67341-01-9 (R)-N-(tert-butoxycarbonyl)phenylglycinol 
• 98-59-9 p-toluenesulfonyl chloride 
• 591-51-5 phenyllithium 

Downstream Products

• 134557-76-9 (R)-(-)-1-<(butoxycarbonyl)amino>-1-phenylethyl azide 
• 830346-51-5 (R)-(2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)carbamic acid tert-butyl ester 
• 65094-32-8 (S)-4-phenyl-9-(3-phenylprop-2-enoyl)-1,5,9-triazacyclotridecan-2-one 
• 126641-91-6 (S)-4-phenyl-1,5,9-triazacyclotridecan-2-one 
• 103365-47-5 (S)-3-(tert-butoxycarbonylamino)-3-phenylpropanoic acid 
• 126568-49-8 Benzoic acid 3-{benzyloxycarbonyl-[4-((S)-3-tert-butoxycarbonylamino-3-phenyl-propionylamino)-butyl]-amino}-propyl ester 
• 126568-48-7 Benzoic acid 3-{benzyl-[4-((S)-3-tert-butoxycarbonylamino-3-phenyl-propionylamino)-butyl]-amino}-propyl ester 
• 126568-50-1 [4-((S)-3-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-butyl]-(3-oxo-propyl)-carbamic acid benzyl ester 
• 126610-78-4 (S)-8-Oxo-6-phenyl-1,5,9-triaza-cyclotridecane-1-carboxylic acid benzyl ester 
• 52249-08-8 tetrahydroperiphylline 

Relevant articles and documents

Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers

Herein, we report the discovery of a novel class of quinazoline carboxamides as dual p70S6k/Akt inhibitors for the treatment of tumors driven by alterations to the PI3K/Akt/mTOR (PAM) pathway. Through the screening of in-house proprietary kinase library, 4-benzylamino-quinazoline-8-carboxylic acid amide 1 stood out, with sub-micromolar p70S6k biochemical activity, as the starting point for a structurally enabled p70S6K/Akt dual inhibitor program that led to the discovery of M2698, a dual p70S6k/Akt inhibitor. M2698 is kinase selective, possesses favorable physical, chemical, and DMPK profiles, is orally available and well tolerated, and displayed tumor control in multiple in vivo studies of PAM pathway-driven tumors.

Selenium promoted synthesis of enantiopure pyrrolidines starting from chiral aminoalcohols

Starting from commercially available enantiomerically pure aminoalcohols and using simple conversions promoted by organoselenium reagents, several enantiomerically pure substituted pyrrolidines were prepared. After double protections (R)- or (S)-2-phenylg

Heterocyclizations of N-Boc derivatives of β-amino alcohols and thio analogs: an unusual case of the Thorpe-Ingold effect

Enantiopure oxazolidin-2-ones were synthesized from chiral N-Boc β-aminoalcohols which underwent a cyclization upon treatment with tosyl chloride.This reaction was strongly accelerated in the case of carbamates derived from N-methylated amines.A similar heterocyclization was observed with dithiocarbamates, ie sulfur analogs of carbamates.The rate enhancement due to the nitrogen substitution was studied by AM1 calculations. - Keywords: carbamate; dithiocarbamate; oxazolidinone; thiazolidinone; AM1 calculations