1266381-24-1

Basic information

• Product Name: N,N-diethyl-2-methoxy-5-t-butylbenzamide
• Synonyms: N,N-diethyl-2-methoxy-5-t-butylbenzamide
• CAS NO: 1266381-24-1
• Molecular Weight: 263.38
• Mol File: 1266381-24-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N,N-diethyl-2-methoxy-5-t-butylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-2-methoxy-5-t-butylbenzamide(1266381-24-1)
• EPA Substance Registry System: N,N-diethyl-2-methoxy-5-t-butylbenzamide(1266381-24-1)

Safety Data

• Hazardous Substances Data: 1266381-24-1(Hazardous Substances Data)

Upstream product

• 28460-09-5 N,N-diethyl-4-tert-butylphenyl carbamate 
• 98-54-4 para-tert-butylphenol 
• 698377-42-3 5-(tert-butyl)-N,N-diethyl-2-hydroxybenzamide 
• 77-78-1 dimethyl sulfate 
• 73469-54-2 5-tert-butyl-2-methoxybenzoic acid 
• 109-89-7 diethylamine 

Downstream Products

• 698377-42-3 5-(tert-butyl)-N,N-diethyl-2-hydroxybenzamide 

Relevant articles and documents

Beyond directed ortho metalation: Ru-catalyzed CAr-O activation/cross-coupling reaction by amide chelation

Disclosed is a new, catalytic, and general methodology for the chemical synthesis of biaryl, heterobiaryl, and polyaryl molecules by the cross-coupling of o-methoxybenzamides with aryl boroneopentylates. The reaction is based on the activation of the unreactive C-OMe bond by the proximate amide directing group using catalytic RuH2(CO)(PPh3)3 conditions. A one-step, base-free coupling process is thereby established that has the potential to supersede the useful two-step directed ortho metalation/cross- coupling reaction involving cryogenic temperature and strong base conditions. High regioselectivity, orthogonality with the Suzuki-Miyaura reaction, operational simplicity, minimum waste, and convenient scale-up make these reactions suitable for industrial applications.