126641-86-9

Basic information

• Product Name: (R)-acetoxy(4-chlorophenyl)acetonitrile
• Synonyms: (R)-acetoxy(4-chlorophenyl)acetonitrile
• CAS NO: 126641-86-9
• Molecular Weight: 209.632
• Mol File: 126641-86-9.mol
• Article Data: 30

Chemical Properties

• CAS DataBase Reference: (R)-acetoxy(4-chlorophenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-acetoxy(4-chlorophenyl)acetonitrile(126641-86-9)
• EPA Substance Registry System: (R)-acetoxy(4-chlorophenyl)acetonitrile(126641-86-9)

Safety Data

• Hazardous Substances Data: 126641-86-9(Hazardous Substances Data)

Upstream product

• 108-22-5 Isopropenyl acetate 
• 104-88-1 4-chlorobenzaldehyde 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 13312-83-9 4-chloromandelonitrile 
• 108-24-7 acetic anhydride 
• 99074-23-4 cyano(4-chlorophenyl)methyl acetate 
• 3282-30-2 pivaloyl chloride 
• 412296-10-7 (R)-2-(4-chlorophenyl)-2-(trimethylsiloxy)acetonitrile 
• 66985-46-4 (+/-)-2-(4-chlorophenyl)-2-(trimethylsiloxy)-acetonitrile 
• 631-57-2 Acetyl cyanide 
• 13312-83-9 (R)-(+)-4-chloromandelonitrile 
• 75-36-5 acetyl chloride 
• 151-50-8 potassium cyanide 
• 69739-34-0 t-butyldimethylsiyl triflate 

Relevant articles and documents

Supported Ionic Liquid-Like Phases (SILLPs) as Immobilised Catalysts for the Multistep and Multicatalytic Continuous Flow Synthesis of Chiral Cyanohydrins

Supported Ionic Liquid-Like Phases have been found to be efficient organocatalysts for the synthesis of cyanohydrin esters under solvent-free conditions by an “electrophile-nucleophile dual activation” based on hydrogen bond formation. The combination of

Preparation of chitosan-supported urea materials and their application in some organocatalytic procedures

An efficient and mild procedure was developed for the preparation of three chitosan-supported ureas containing electron-withdrawing groups. These catalysts were characterized and employed as organocatalysts in different transformations, including the enan

Dual Lewis Acid/Lewis Base Catalyzed Acylcyanation of Aldehydes: A Mechanistic Study

A mechanistic investigation, which included a Hammett correlation analysis, evaluation of the effect of variation of catalyst composition, and low-temperature NMR spectroscopy studies, of the Lewis acid-Lewis base catalyzed addition of acetyl cyanide to prochiral aldehydes provides support for a reaction route that involves Lewis base activation of the acyl cyanide with formation of a potent acylating agent and cyanide ion. The cyanide ion adds to the carbonyl group of the Lewis acid activated aldehyde. O-Acylation by the acylated Lewis base to form the final cyanohydrin ester occurs prior to decomplexation from titanium. For less reactive aldehydes, the addition of cyanide is the rate-determining step, whereas, for more reactive, electron-deficient aldehydes, cyanide addition is rapid and reversible and is followed by rate-limiting acylation. The resting state of the catalyst lies outside the catalytic cycle and is believed to be a monomeric titanium complex with two alcoholate ligands, which only slowly converts into the product.