1266784-23-9

Basic information

• Product Name: (RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid
• Synonyms: (RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid
• CAS NO: 1266784-23-9
• Molecular Weight: 262.078
• Mol File: 1266784-23-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 342.2±42.0 °C(Predicted)
• Density: 1.655±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid(1266784-23-9)
• EPA Substance Registry System: (RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid(1266784-23-9)

Safety Data

• Hazardous Substances Data: 1266784-23-9(Hazardous Substances Data)

Usage

Description

(RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid is a complex chemical compound that is an amino acid derivative. It features a substituted phenyl ring and a propionic acid side chain, with the bromine and fluorine atoms in the phenyl ring providing unique properties. This chiral compound exists in two mirror-image forms (R and S enantiomers), which can exhibit different biological activities based on their stereochemistry. As a result, (RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid holds intriguing chemical and pharmacological potential.

Uses

Used in Pharmaceutical Industry:
(RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid is used as an intermediate in the synthesis of various pharmaceutical compounds due to its unique molecular structure and the potential for different biological activities based on its stereochemistry.
Used in Chemical Research:
(RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid serves as a valuable research tool for studying the effects of stereochemistry on biological activity, as well as for exploring its potential applications in the development of new drugs and therapies.
Used in Material Science:
The unique properties of (RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid, such as the presence of bromine and fluorine atoms, may also make it useful in the development of new materials with specific characteristics for various industrial applications.

Upstream product

• 1374765-83-9 2-amino-2-(5-bromo-2-fluorophenyl)propanoic acid hydrochloride 
• 1350523-51-1 rac-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionitrile 
• 1266784-17-1 (RS)-5-(5-bromo-2-fluorophenyl)-5-methyl-imidazolidine-2,4-dione 
• 910912-20-8 5-bromo-2-fluoro-N-methoxy-N-methylbenzamide 
• 198477-89-3 1-(5-bromo-2-fluorophenyl)ethan-1-one 
• 146328-85-0 5-bromo-2-fluoro-benzoic acid 

Downstream Products

• 1266784-18-2 rac-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid methyl ester 
• 1266784-13-7 rac-5-(5-bromo-2-fluorophenyl)-5-methylmorpholin-3-one 
• 1266784-24-0 (RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propan-1-ol 
• 1266784-29-5 rac-N-(2-(5-bromo-2-fluorophenyl)-1-hydroxypropan-2-yl)-2-chloroacetamide 
• 1266784-31-9 (RS)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one 
• 1266784-38-6 (R)-(+)-N-[1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide 
• 1266784-40-0 (S)-(-)-N-[1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide 
• 1266785-76-5 N-[(RS)-1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1-methyl-ethyl]-3-phenyl-acrylamide 
• 1352415-71-4 N-{3-[(3R)-5-amino-3-methyl-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide 
• 1266786-51-9 N-{3-[(3R)-5-amino-3-methyl-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-5-chloropyridine-2-carboxamide 
• 1266785-90-3 (5R)-5-(5-amino-2-fluorophenyl)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine 
• 1266785-14-1 (5R)-5-(5-Bromo-2-fluorophenyl)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine 
• 1392104-98-1 (5R)-5-(5-bromo-2-fluorophenyl)-5-methylmorpholine-3-thione 
• 1228571-14-9 (2R)-2-amino-2-(5-bromo-2-fluorophenyl)propan-1-ol 

Relevant articles and documents

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1,4-Oxazines are presented, which show good in vitro inhibition in enzymatic and cellular BACE1 assays. We describe lead optimization focused on reducing the amidine pKa while optimizing interactions in the BACE1 active site. Our strategy permi

5-(3-AMINOPHENYL)-5-ALKYL-5,6-DIHYDRO-2H-[1,4]OXAZIN-3-AMINE DERIVATIVES

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6-DIFLUOROMETHYL-5,6-DIHYDRO-2H-[1,4]OXAZIN-3-AMINE DERIVATIVES

The invention relates to novel 6-difluoromethyl-5,6-dihydro-2H-[l,4]oxazin-3- amine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceut